Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation

Pierre De Rossi; Toshihiro Nomura; Robert J. Andrew; Nicolas Y. Masse; Vandana Sampathkumar; Timothy F. Musial; Ari Sudwarts; Aleksandra J. Recupero; Thomas Le Metayer; Mitchell T. Hansen; Ha Na Shim; Sofia V. Krause; David J. Freedman; Vytas P. Bindokas; Narayanan Kasthuri; Daniel A. Nicholson; Anis Contractor; Gopal Thinakaran

doi:10.1016/j.celrep.2020.02.026

Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation

Pierre De Rossi, Toshihiro Nomura, Robert J. Andrew, Nicolas Y. Masse, Vandana Sampathkumar, Timothy F. Musial, Ari Sudwarts, Aleksandra J. Recupero, Thomas Le Metayer, Mitchell T. Hansen, Ha Na Shim, Sofia V. Krause, David J. Freedman, Vytas P. Bindokas, Narayanan Kasthuri, Daniel A. Nicholson, Anis Contractor, Gopal Thinakaran^*

^*Corresponding author for this work

Physiology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

BIN1 is a significant risk factor for late-onset Alzheimer disease. BIN1 has a general role in endocytosis and membrane dynamics in non-neuronal cells. De Rossi et al. show that BIN1 localizes to presynaptic terminals and plays an indispensable role in excitatory synaptic transmission by regulating neurotransmitter vesicle dynamics.

Original language	English (US)
Pages (from-to)	3520-3535.e7
Journal	Cell reports
Volume	30
Issue number	10
DOIs	https://doi.org/10.1016/j.celrep.2020.02.026
State	Published - Mar 10 2020

Keywords

3D EM reconstruction
Amphiphysin 2
BIN1
Morris water maze
STED
dSTORM
late-onset Alzheimer disease
release probability
super-resolution
synaptic physiology

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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De Rossi, P., Nomura, T., Andrew, R. J., Masse, N. Y., Sampathkumar, V., Musial, T. F., Sudwarts, A., Recupero, A. J., Le Metayer, T., Hansen, M. T., Shim, H. N., Krause, S. V., Freedman, D. J., Bindokas, V. P., Kasthuri, N., Nicholson, D. A., Contractor, A., & Thinakaran, G. (2020). Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation. Cell reports, 30(10), 3520-3535.e7. https://doi.org/10.1016/j.celrep.2020.02.026

De Rossi, Pierre ; Nomura, Toshihiro ; Andrew, Robert J. ; Masse, Nicolas Y. ; Sampathkumar, Vandana ; Musial, Timothy F. ; Sudwarts, Ari ; Recupero, Aleksandra J. ; Le Metayer, Thomas ; Hansen, Mitchell T. ; Shim, Ha Na ; Krause, Sofia V. ; Freedman, David J. ; Bindokas, Vytas P. ; Kasthuri, Narayanan ; Nicholson, Daniel A. ; Contractor, Anis ; Thinakaran, Gopal. / Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation. In: Cell reports. 2020 ; Vol. 30, No. 10. pp. 3520-3535.e7.

@article{f0b2ee4622924db2a853c1b5759c0c88,

title = "Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation",

abstract = "BIN1 is a significant risk factor for late-onset Alzheimer disease. BIN1 has a general role in endocytosis and membrane dynamics in non-neuronal cells. De Rossi et al. show that BIN1 localizes to presynaptic terminals and plays an indispensable role in excitatory synaptic transmission by regulating neurotransmitter vesicle dynamics.",

keywords = "3D EM reconstruction, Amphiphysin 2, BIN1, Morris water maze, STED, dSTORM, late-onset Alzheimer disease, release probability, super-resolution, synaptic physiology",

author = "{De Rossi}, Pierre and Toshihiro Nomura and Andrew, {Robert J.} and Masse, {Nicolas Y.} and Vandana Sampathkumar and Musial, {Timothy F.} and Ari Sudwarts and Recupero, {Aleksandra J.} and {Le Metayer}, Thomas and Hansen, {Mitchell T.} and Shim, {Ha Na} and Krause, {Sofia V.} and Freedman, {David J.} and Bindokas, {Vytas P.} and Narayanan Kasthuri and Nicholson, {Daniel A.} and Anis Contractor and Gopal Thinakaran",

note = "Funding Information: We thank Xiaoxi Zhuang for advice on behavioral experiments and statistical analysis. This work was supported by National Institutes of Health grants AG054223 and AG056061 (to G.T.), AG017139 and K02 AG050767 (to D.A.N.), and R01MH099114 (to A.C.); by the Cure Alzheimer's Fund (G.T.); by the Alzheimer's Association (P.D.R.); and by fellowships from the BrightFocus Foundation (P.D.R.) and the Illinois Department of Public Health (R.J.A.). Fluorescence imaging was performed at the Integrated Microscopy Core Facility at the University of Chicago (supported by grant S10OD010649 ). ",

year = "2020",

month = mar,

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doi = "10.1016/j.celrep.2020.02.026",

language = "English (US)",

volume = "30",

pages = "3520--3535.e7",

journal = "Cell Reports",

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De Rossi, P, Nomura, T, Andrew, RJ, Masse, NY, Sampathkumar, V, Musial, TF, Sudwarts, A, Recupero, AJ, Le Metayer, T, Hansen, MT, Shim, HN, Krause, SV, Freedman, DJ, Bindokas, VP, Kasthuri, N, Nicholson, DA, Contractor, A & Thinakaran, G 2020, 'Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation', Cell reports, vol. 30, no. 10, pp. 3520-3535.e7. https://doi.org/10.1016/j.celrep.2020.02.026

Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation. / De Rossi, Pierre; Nomura, Toshihiro; Andrew, Robert J.; Masse, Nicolas Y.; Sampathkumar, Vandana; Musial, Timothy F.; Sudwarts, Ari; Recupero, Aleksandra J.; Le Metayer, Thomas; Hansen, Mitchell T.; Shim, Ha Na; Krause, Sofia V.; Freedman, David J.; Bindokas, Vytas P.; Kasthuri, Narayanan; Nicholson, Daniel A.; Contractor, Anis; Thinakaran, Gopal.

In: Cell reports, Vol. 30, No. 10, 10.03.2020, p. 3520-3535.e7.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation

AU - De Rossi, Pierre

AU - Nomura, Toshihiro

AU - Andrew, Robert J.

AU - Masse, Nicolas Y.

AU - Sampathkumar, Vandana

AU - Musial, Timothy F.

AU - Sudwarts, Ari

AU - Recupero, Aleksandra J.

AU - Le Metayer, Thomas

AU - Hansen, Mitchell T.

AU - Shim, Ha Na

AU - Krause, Sofia V.

AU - Freedman, David J.

AU - Bindokas, Vytas P.

AU - Kasthuri, Narayanan

AU - Nicholson, Daniel A.

AU - Contractor, Anis

AU - Thinakaran, Gopal

N1 - Funding Information: We thank Xiaoxi Zhuang for advice on behavioral experiments and statistical analysis. This work was supported by National Institutes of Health grants AG054223 and AG056061 (to G.T.), AG017139 and K02 AG050767 (to D.A.N.), and R01MH099114 (to A.C.); by the Cure Alzheimer's Fund (G.T.); by the Alzheimer's Association (P.D.R.); and by fellowships from the BrightFocus Foundation (P.D.R.) and the Illinois Department of Public Health (R.J.A.). Fluorescence imaging was performed at the Integrated Microscopy Core Facility at the University of Chicago (supported by grant S10OD010649 ).

PY - 2020/3/10

Y1 - 2020/3/10

N2 - BIN1 is a significant risk factor for late-onset Alzheimer disease. BIN1 has a general role in endocytosis and membrane dynamics in non-neuronal cells. De Rossi et al. show that BIN1 localizes to presynaptic terminals and plays an indispensable role in excitatory synaptic transmission by regulating neurotransmitter vesicle dynamics.

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KW - 3D EM reconstruction

KW - Amphiphysin 2

KW - BIN1

KW - Morris water maze

KW - STED

KW - dSTORM

KW - late-onset Alzheimer disease

KW - release probability

KW - super-resolution

KW - synaptic physiology

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DO - 10.1016/j.celrep.2020.02.026

M3 - Article

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AN - SCOPUS:85080975846

VL - 30

SP - 3520-3535.e7

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

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