@article{f0b2ee4622924db2a853c1b5759c0c88,
title = "Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation",
abstract = "BIN1 is a significant risk factor for late-onset Alzheimer disease. BIN1 has a general role in endocytosis and membrane dynamics in non-neuronal cells. De Rossi et al. show that BIN1 localizes to presynaptic terminals and plays an indispensable role in excitatory synaptic transmission by regulating neurotransmitter vesicle dynamics.",
keywords = "3D EM reconstruction, Amphiphysin 2, BIN1, Morris water maze, STED, dSTORM, late-onset Alzheimer disease, release probability, super-resolution, synaptic physiology",
author = "{De Rossi}, Pierre and Toshihiro Nomura and Andrew, {Robert J.} and Masse, {Nicolas Y.} and Vandana Sampathkumar and Musial, {Timothy F.} and Ari Sudwarts and Recupero, {Aleksandra J.} and {Le Metayer}, Thomas and Hansen, {Mitchell T.} and Shim, {Ha Na} and Krause, {Sofia V.} and Freedman, {David J.} and Bindokas, {Vytas P.} and Narayanan Kasthuri and Nicholson, {Daniel A.} and Anis Contractor and Gopal Thinakaran",
note = "Funding Information: We thank Xiaoxi Zhuang for advice on behavioral experiments and statistical analysis. This work was supported by National Institutes of Health grants AG054223 and AG056061 (to G.T.), AG017139 and K02 AG050767 (to D.A.N.), and R01MH099114 (to A.C.); by the Cure Alzheimer's Fund (G.T.); by the Alzheimer's Association (P.D.R.); and by fellowships from the BrightFocus Foundation (P.D.R.) and the Illinois Department of Public Health (R.J.A.). Fluorescence imaging was performed at the Integrated Microscopy Core Facility at the University of Chicago (supported by grant S10OD010649 ). Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = mar,
day = "10",
doi = "10.1016/j.celrep.2020.02.026",
language = "English (US)",
volume = "30",
pages = "3520--3535.e7",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "10",
}