Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation

Pierre De Rossi, Toshihiro Nomura, Robert J. Andrew, Nicolas Y. Masse, Vandana Sampathkumar, Timothy F. Musial, Ari Sudwarts, Aleksandra J. Recupero, Thomas Le Metayer, Mitchell T. Hansen, Ha Na Shim, Sofia V. Krause, David J. Freedman, Vytas P. Bindokas, Narayanan Kasthuri, Daniel A. Nicholson, Anis Contractor, Gopal Thinakaran*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


BIN1 is a significant risk factor for late-onset Alzheimer disease. BIN1 has a general role in endocytosis and membrane dynamics in non-neuronal cells. De Rossi et al. show that BIN1 localizes to presynaptic terminals and plays an indispensable role in excitatory synaptic transmission by regulating neurotransmitter vesicle dynamics.

Original languageEnglish (US)
Pages (from-to)3520-3535.e7
JournalCell reports
Issue number10
StatePublished - Mar 10 2020


  • 3D EM reconstruction
  • Amphiphysin 2
  • BIN1
  • Morris water maze
  • STED
  • dSTORM
  • late-onset Alzheimer disease
  • release probability
  • super-resolution
  • synaptic physiology

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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