Neuronal intrinsic barriers for axon regeneration in the adult CNS

Fang Sun, Zhigang He*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

140 Scopus citations

Abstract

A major reason for the devastating and permanent disabilities after spinal cord and other types of CNS injury is the failure of injured axons to regenerate and to re-build the functional circuits. Thus, a long-standing goal has been to develop strategies that could promote axon regeneration and restore functions. Recent studies revealed that simply removing extracellular inhibitory activities is insufficient for successful axon regeneration in the adult CNS. On the other side, evidence from different species and different models is accumulating to support the notion that diminished intrinsic regenerative ability of mature neurons is a major contributor to regeneration failure. This review will summarize the molecular mechanisms regulating intrinsic axon growth capacity in the adult CNS and discuss potential implications for therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)510-518
Number of pages9
JournalCurrent opinion in neurobiology
Volume20
Issue number4
DOIs
StatePublished - Aug 2010
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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