Neuronal nicotinic acetylcholine receptors: A new target site of ethanol

Toshio Narahashi*, Gary L. Aistrup, William Marszalec, Keiichi Nagata

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

90 Scopus citations

Abstract

Whereas a variety of neuroreceptors and ion channels have been demonstrated to be affected by ethanol including GABA(A) receptors, NMDA receptors, non-NMDA glutamate receptors, 5-HT3 receptors and voltage-gated calcium channels, neuronal nicotinic acetylcholine receptors (nnAChRs) have recently emerged as a new target site of ethanol. The nnAChRs are different from the muscle type nicotinic AChRs with respect to their molecular architecture and pharmacology. This article briefly reviews the structure, distribution and function of nnAChRs for which a considerable amount of information has been rapidly accumulated during the past 5-10 years. The potent and unique action of ethanol on nnAChRs has been unveiled only during the past few years. Most recent developments along this line of ethanol action are discussed in this paper. Copyright (C) 1999 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)131-141
Number of pages11
JournalNeurochemistry International
Volume35
Issue number2
DOIs
StatePublished - Aug 1999

Keywords

  • Alcohols
  • Ethanol
  • Nicotinic acetylcholine receptors
  • α-Bungarotoxin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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