Neuronal nicotinic acetylcholine receptors: A new target site of ethanol

Toshio Narahashi; Gary L. Aistrup; William Marszalec; Keiichi Nagata

doi:10.1016/S0197-0186(99)00055-8

Neuronal nicotinic acetylcholine receptors: A new target site of ethanol

Toshio Narahashi^*, Gary L. Aistrup, William Marszalec, Keiichi Nagata

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

91 Scopus citations

Abstract

Whereas a variety of neuroreceptors and ion channels have been demonstrated to be affected by ethanol including GABA(A) receptors, NMDA receptors, non-NMDA glutamate receptors, 5-HT₃ receptors and voltage-gated calcium channels, neuronal nicotinic acetylcholine receptors (nnAChRs) have recently emerged as a new target site of ethanol. The nnAChRs are different from the muscle type nicotinic AChRs with respect to their molecular architecture and pharmacology. This article briefly reviews the structure, distribution and function of nnAChRs for which a considerable amount of information has been rapidly accumulated during the past 5-10 years. The potent and unique action of ethanol on nnAChRs has been unveiled only during the past few years. Most recent developments along this line of ethanol action are discussed in this paper. Copyright (C) 1999 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	131-141
Number of pages	11
Journal	Neurochemistry International
Volume	35
Issue number	2
DOIs	https://doi.org/10.1016/S0197-0186(99)00055-8
State	Published - Aug 1999

Funding

The author’s work described in this paper was supported by NIH grants R01 AA07836, R01 NS14144 and F32 AA05447. Thanks are due to Julia Irizarry for secretarial assistance.

Keywords

Alcohols
Ethanol
Nicotinic acetylcholine receptors
α-Bungarotoxin

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Cell Biology

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10.1016/S0197-0186(99)00055-8

Cite this

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title = "Neuronal nicotinic acetylcholine receptors: A new target site of ethanol",

abstract = "Whereas a variety of neuroreceptors and ion channels have been demonstrated to be affected by ethanol including GABA(A) receptors, NMDA receptors, non-NMDA glutamate receptors, 5-HT3 receptors and voltage-gated calcium channels, neuronal nicotinic acetylcholine receptors (nnAChRs) have recently emerged as a new target site of ethanol. The nnAChRs are different from the muscle type nicotinic AChRs with respect to their molecular architecture and pharmacology. This article briefly reviews the structure, distribution and function of nnAChRs for which a considerable amount of information has been rapidly accumulated during the past 5-10 years. The potent and unique action of ethanol on nnAChRs has been unveiled only during the past few years. Most recent developments along this line of ethanol action are discussed in this paper. Copyright (C) 1999 Elsevier Science Ltd.",

keywords = "Alcohols, Ethanol, Nicotinic acetylcholine receptors, α-Bungarotoxin",

author = "Toshio Narahashi and Aistrup, {Gary L.} and William Marszalec and Keiichi Nagata",

note = "Funding Information: The author{\textquoteright}s work described in this paper was supported by NIH grants R01 AA07836, R01 NS14144 and F32 AA05447. Thanks are due to Julia Irizarry for secretarial assistance.",

year = "1999",

month = aug,

doi = "10.1016/S0197-0186(99)00055-8",

language = "English (US)",

volume = "35",

pages = "131--141",

journal = "Neurochemistry International",

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T2 - A new target site of ethanol

AU - Narahashi, Toshio

AU - Aistrup, Gary L.

AU - Marszalec, William

AU - Nagata, Keiichi

N1 - Funding Information: The author’s work described in this paper was supported by NIH grants R01 AA07836, R01 NS14144 and F32 AA05447. Thanks are due to Julia Irizarry for secretarial assistance.

PY - 1999/8

Y1 - 1999/8

N2 - Whereas a variety of neuroreceptors and ion channels have been demonstrated to be affected by ethanol including GABA(A) receptors, NMDA receptors, non-NMDA glutamate receptors, 5-HT3 receptors and voltage-gated calcium channels, neuronal nicotinic acetylcholine receptors (nnAChRs) have recently emerged as a new target site of ethanol. The nnAChRs are different from the muscle type nicotinic AChRs with respect to their molecular architecture and pharmacology. This article briefly reviews the structure, distribution and function of nnAChRs for which a considerable amount of information has been rapidly accumulated during the past 5-10 years. The potent and unique action of ethanol on nnAChRs has been unveiled only during the past few years. Most recent developments along this line of ethanol action are discussed in this paper. Copyright (C) 1999 Elsevier Science Ltd.

AB - Whereas a variety of neuroreceptors and ion channels have been demonstrated to be affected by ethanol including GABA(A) receptors, NMDA receptors, non-NMDA glutamate receptors, 5-HT3 receptors and voltage-gated calcium channels, neuronal nicotinic acetylcholine receptors (nnAChRs) have recently emerged as a new target site of ethanol. The nnAChRs are different from the muscle type nicotinic AChRs with respect to their molecular architecture and pharmacology. This article briefly reviews the structure, distribution and function of nnAChRs for which a considerable amount of information has been rapidly accumulated during the past 5-10 years. The potent and unique action of ethanol on nnAChRs has been unveiled only during the past few years. Most recent developments along this line of ethanol action are discussed in this paper. Copyright (C) 1999 Elsevier Science Ltd.

KW - Alcohols

KW - Ethanol

KW - Nicotinic acetylcholine receptors

KW - α-Bungarotoxin

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DO - 10.1016/S0197-0186(99)00055-8

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SN - 0197-0186

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JO - Neurochemistry International

JF - Neurochemistry International

IS - 2

ER -

Neuronal nicotinic acetylcholine receptors: A new target site of ethanol

Abstract

Funding

Keywords

ASJC Scopus subject areas

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