Neuropathic Pain and Pharmacological Treatment

Joost L.M. Jongen*, Guy Hans, Honorio T. Benzon, Frank Huygen, Craig T. Hartrick

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


Neuropathic pain is a serious chronic condition strongly affecting quality of life, which can be relieved but cannot be cured. Apart from symptomatic management, treatment should focus on the underlying disorder. The estimated prevalence is at least 1% to 5% of the general population. Neuropathic pain is characterized both by spontaneous and evoked pain. A diagnosis of neuropathic pain can usually be established based solely on history and neurological examination. Ancillary investigations may include EMG and computerized tomography/magnetic resonance imaging scans, depending on the localization of the suspected lesion. A limited number of agents, primarily directed at symptom control, are currently approved for use in neuropathic pain. A mechanism-based approach to pharmacological intervention supports the use of polypharmacy in neuropathic pain.

Original languageEnglish (US)
Pages (from-to)283-295
Number of pages13
JournalPain Practice
Issue number3
StatePublished - Mar 2014


  • Clinical diagnosis
  • Evidence-based medicine
  • Neuropathic pain
  • Pharmacological management
  • Polypharmacy
  • Review

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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