Neuropathic Tissue Responds Preferentially to Stimulation by Intense Focused Ultrasound

Rowen E. Tych; Michael Gofeld; Jeffrey G. Jarvik; Michel Kliot; John D. Loeser; Abbi M. McClintic; Ryan J. Ollos; Kristin D. Pederson; Rachel E. Sparks; Gregory W. Terman; Pierre D. Mourad

doi:10.1016/j.ultrasmedbio.2012.08.012

Neuropathic Tissue Responds Preferentially to Stimulation by Intense Focused Ultrasound

Rowen E. Tych, Michael Gofeld, Jeffrey G. Jarvik, Michel Kliot, John D. Loeser, Abbi M. McClintic, Ryan J. Ollos, Kristin D. Pederson, Rachel E. Sparks, Gregory W. Terman, Pierre D. Mourad^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We tested the hypothesis that neuropathic tissue is more sensitive to stimulation by intense focused ultrasound (iFU) than control tissue. We created a diffusely neuropathic paw in rats via partial ligation of the sciatic nerve, whose sensitivity to iFU stimulation we compared with sham-surgery and normal control paws. We then applied increasing amounts of iFU (individual 0.2 s pulses at 1.15 MHz) to the rats' paws, assaying for their reliable withdrawal from that stimulation. Neuropathic rats preferentially withdrew their injured paw from iFU at smaller values of iFU intensity (84.2 W/cm² ± 25.5) than did sham surgery (97.7 W/cm² ± 11.9) and normal control (> 223 W/cm²) animals, with greater sensitivity and specificity (85% for neuropathic rats and 50% each of sham surgery and normal control rats). These results directly support our hypothesis as well as Gavrilov's idea that doctors may some day use iFU stimulation to diagnose patients with neuropathies.

Original language	English (US)
Pages (from-to)	111-116
Number of pages	6
Journal	Ultrasound in Medicine and Biology
Volume	39
Issue number	1
DOIs	https://doi.org/10.1016/j.ultrasmedbio.2012.08.012
State	Published - Jan 2013
Externally published	Yes

Keywords

Intense focused ultrasound
Neuropathy
Pain
Pain diagnosis

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Biophysics
Acoustics and Ultrasonics

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10.1016/j.ultrasmedbio.2012.08.012

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title = "Neuropathic Tissue Responds Preferentially to Stimulation by Intense Focused Ultrasound",

abstract = "We tested the hypothesis that neuropathic tissue is more sensitive to stimulation by intense focused ultrasound (iFU) than control tissue. We created a diffusely neuropathic paw in rats via partial ligation of the sciatic nerve, whose sensitivity to iFU stimulation we compared with sham-surgery and normal control paws. We then applied increasing amounts of iFU (individual 0.2 s pulses at 1.15 MHz) to the rats' paws, assaying for their reliable withdrawal from that stimulation. Neuropathic rats preferentially withdrew their injured paw from iFU at smaller values of iFU intensity (84.2 W/cm2 ± 25.5) than did sham surgery (97.7 W/cm2 ± 11.9) and normal control (> 223 W/cm2) animals, with greater sensitivity and specificity (85% for neuropathic rats and 50% each of sham surgery and normal control rats). These results directly support our hypothesis as well as Gavrilov's idea that doctors may some day use iFU stimulation to diagnose patients with neuropathies.",

keywords = "Intense focused ultrasound, Neuropathy, Pain, Pain diagnosis",

author = "Tych, {Rowen E.} and Michael Gofeld and Jarvik, {Jeffrey G.} and Michel Kliot and Loeser, {John D.} and McClintic, {Abbi M.} and Ollos, {Ryan J.} and Pederson, {Kristin D.} and Sparks, {Rachel E.} and Terman, {Gregory W.} and Mourad, {Pierre D.}",

note = "Funding Information: This work received financial support from the Life Sciences Discovery Fund of Washington State , the NIH ( UL1 RR025014, R41 NS 049719-01 ), the Veterans Administration and direct funding from PhysioSonics, Inc . This material is based upon work supported in part by the U.S. Department of Veterans Affairs' Office of Research and Development Rehabilitation R&D Program, from NIH ( UL1 RR025014, R41 NS 049719-01 ), and the Life Sciences Discovery Fund of the State of Washington.",

year = "2013",

month = jan,

doi = "10.1016/j.ultrasmedbio.2012.08.012",

language = "English (US)",

volume = "39",

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journal = "Ultrasound in Medicine and Biology",

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AU - Tych, Rowen E.

AU - Gofeld, Michael

AU - Jarvik, Jeffrey G.

AU - Kliot, Michel

AU - Loeser, John D.

AU - McClintic, Abbi M.

AU - Ollos, Ryan J.

AU - Pederson, Kristin D.

AU - Sparks, Rachel E.

AU - Terman, Gregory W.

AU - Mourad, Pierre D.

N1 - Funding Information: This work received financial support from the Life Sciences Discovery Fund of Washington State , the NIH ( UL1 RR025014, R41 NS 049719-01 ), the Veterans Administration and direct funding from PhysioSonics, Inc . This material is based upon work supported in part by the U.S. Department of Veterans Affairs' Office of Research and Development Rehabilitation R&D Program, from NIH ( UL1 RR025014, R41 NS 049719-01 ), and the Life Sciences Discovery Fund of the State of Washington.

PY - 2013/1

Y1 - 2013/1

N2 - We tested the hypothesis that neuropathic tissue is more sensitive to stimulation by intense focused ultrasound (iFU) than control tissue. We created a diffusely neuropathic paw in rats via partial ligation of the sciatic nerve, whose sensitivity to iFU stimulation we compared with sham-surgery and normal control paws. We then applied increasing amounts of iFU (individual 0.2 s pulses at 1.15 MHz) to the rats' paws, assaying for their reliable withdrawal from that stimulation. Neuropathic rats preferentially withdrew their injured paw from iFU at smaller values of iFU intensity (84.2 W/cm2 ± 25.5) than did sham surgery (97.7 W/cm2 ± 11.9) and normal control (> 223 W/cm2) animals, with greater sensitivity and specificity (85% for neuropathic rats and 50% each of sham surgery and normal control rats). These results directly support our hypothesis as well as Gavrilov's idea that doctors may some day use iFU stimulation to diagnose patients with neuropathies.

AB - We tested the hypothesis that neuropathic tissue is more sensitive to stimulation by intense focused ultrasound (iFU) than control tissue. We created a diffusely neuropathic paw in rats via partial ligation of the sciatic nerve, whose sensitivity to iFU stimulation we compared with sham-surgery and normal control paws. We then applied increasing amounts of iFU (individual 0.2 s pulses at 1.15 MHz) to the rats' paws, assaying for their reliable withdrawal from that stimulation. Neuropathic rats preferentially withdrew their injured paw from iFU at smaller values of iFU intensity (84.2 W/cm2 ± 25.5) than did sham surgery (97.7 W/cm2 ± 11.9) and normal control (> 223 W/cm2) animals, with greater sensitivity and specificity (85% for neuropathic rats and 50% each of sham surgery and normal control rats). These results directly support our hypothesis as well as Gavrilov's idea that doctors may some day use iFU stimulation to diagnose patients with neuropathies.

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Neuropathic Tissue Responds Preferentially to Stimulation by Intense Focused Ultrasound

Abstract

Keywords

ASJC Scopus subject areas

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