Neuropathology in Consecutive Forensic Consultation Cases with a History of Remote Traumatic Brain Injury

Rudy J. Castellani*, Margaret Smith, Kristi Bailey, George Perry, Joyce L. Dejong

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Traumatic brain injury (TBI) is widely assumed to be causal in neurodegenerative disease, based on epidemiological surveys demonstrating an increased risk of Alzheimer disease (AD) following TBI, and on recent theories surrounding repetitive head movement. We tested this assumption by evaluating 30 consecutive forensic examinations in which neuropathology consultation was sought, and in which a history of remote TBI was uncovered during the course of the investigation. In this series, there was a high frequency of psychiatric co-morbidities (100%), remote contusion (90%), and seizures (63%). Extent of proteinopathy showed no differences with age-matched controls. A subset of the cases showed focal geographic tauopathy that correlated with older age at autopsy, but had no correlation with clinical signs, and was minimal in comparison with the encephalomalacia secondary to trauma. The results suggest that cerebral contusion and post-traumatic epilepsy may be over-represented in civilian TBI, while structural brain damage from trauma is the predominant cause of morbidity following TBI. We found no evidence that TBI initiates a progressive proteinopathy.

Original languageEnglish (US)
Pages (from-to)683-691
Number of pages9
JournalJournal of Alzheimer's Disease
Issue number3
StatePublished - 2019


  • Alzheimer's disease
  • Amyloid-β
  • contusion
  • epilepsy
  • neurodegenerative disease
  • phosphorylated tau
  • traumatic brain injury

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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