Neuropathology in Consecutive Forensic Consultation Cases with a History of Remote Traumatic Brain Injury

Rudy J. Castellani*, Margaret Smith, Kristi Bailey, George Perry, Joyce L. Dejong

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


Traumatic brain injury (TBI) is widely assumed to be causal in neurodegenerative disease, based on epidemiological surveys demonstrating an increased risk of Alzheimer disease (AD) following TBI, and on recent theories surrounding repetitive head movement. We tested this assumption by evaluating 30 consecutive forensic examinations in which neuropathology consultation was sought, and in which a history of remote TBI was uncovered during the course of the investigation. In this series, there was a high frequency of psychiatric co-morbidities (100%), remote contusion (90%), and seizures (63%). Extent of proteinopathy showed no differences with age-matched controls. A subset of the cases showed focal geographic tauopathy that correlated with older age at autopsy, but had no correlation with clinical signs, and was minimal in comparison with the encephalomalacia secondary to trauma. The results suggest that cerebral contusion and post-traumatic epilepsy may be over-represented in civilian TBI, while structural brain damage from trauma is the predominant cause of morbidity following TBI. We found no evidence that TBI initiates a progressive proteinopathy.

Original languageEnglish (US)
Title of host publicationHandbook of Traumatic Brain Injury and Neurodegeneration
EditorsRudy J. Castellani
PublisherIOS Press
Number of pages9
ISBN (Electronic)9781643680644
StatePublished - 2020

Publication series

NameAdvances in Alzheimer's Disease
ISSN (Print)2210-5727
ISSN (Electronic)2210-5735


  • Alzheimer's disease
  • amyloid-β
  • contusion
  • epilepsy
  • neurodegenerative disease
  • phosphorylated tau
  • traumatic brain injury

ASJC Scopus subject areas

  • Clinical Neurology


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