Abstract
Cell surface ectopeptidase activity of purified, cultured large vessel and microvessel-derived endothelial cells (EC) was studied. Degradation of thyrotropin releasing hormone (TRH), and production of cyclo-His-Pro was significantly increased (P < 0.001) in large vessel EC compared with microcapillary EC. Since the rate of catabolism in the microvascular capillary bed is 5 times less than that in the large vessel wall, peptide concentrations are likely maintained longer in close proximity to their site of biosynthesis, where they are presumably most active.
Original language | English (US) |
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Pages (from-to) | 397-401 |
Number of pages | 5 |
Journal | Brain research |
Volume | 499 |
Issue number | 2 |
DOIs | |
State | Published - Oct 16 1989 |
Keywords
- Aminopeptidase
- Endothelial cell
- Neuropeptide
- Thyrotropin releasing hormone
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology