Neuropeptide degradation by large vessel and microvessel-derived endothelial cells in vitro: cell surface catabolism of thyrotropin releasing hormone (TRH)

Jack M. Rozental*, Grazyna Kaminska, Joel Turner, Thomas Schwartz, Victoria Cadahia, Benjamin R. Brooks

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Cell surface ectopeptidase activity of purified, cultured large vessel and microvessel-derived endothelial cells (EC) was studied. Degradation of thyrotropin releasing hormone (TRH), and production of cyclo-His-Pro was significantly increased (P < 0.001) in large vessel EC compared with microcapillary EC. Since the rate of catabolism in the microvascular capillary bed is 5 times less than that in the large vessel wall, peptide concentrations are likely maintained longer in close proximity to their site of biosynthesis, where they are presumably most active.

Original languageEnglish (US)
Pages (from-to)397-401
Number of pages5
JournalBrain research
Volume499
Issue number2
DOIs
StatePublished - Oct 16 1989

Keywords

  • Aminopeptidase
  • Endothelial cell
  • Neuropeptide
  • Thyrotropin releasing hormone

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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