Neuropeptide Y in Frontal Cortex Is Not Altered in Major Depression

Gregory A. Ordway*, Craig A. Stockmeier, Herbert Y. Meltzer, James C. Overholser, Susan Jaconetta, Peter S. Widdowson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Abstract: Previously, we reported a modest but significant reduction in the concentration of neuropeptide Y in frontal cortices from victims of suicide relative to age‐matched natural or accidental death control subjects. The reduction in neuropeptide Y appeared to be greatest in a subgroup of victims of suicide for which there was indirect evidence of histories of depression. We pursued these initial findings in the present study by measuring neuropeptide Y concentrations in frontal cortices from natural or accidental death control subjects and from suicide victims in whom a firm diagnosis of major depression was established by psychiatric autopsy. Because several subjects with major depression had a comorbid diagnosis of alcoholism, a group of victims of suicide that had an Axis I diagnosis of alcohol dependence was also studied. No significant differences in neuropeptide Y concentrations were observed between control subjects and victims of suicide with major depression or victims of suicide with alcohol dependence. These findings do not support a role for neuropeptide Y in major depression.

Original languageEnglish (US)
Pages (from-to)1646-1650
Number of pages5
JournalJournal of neurochemistry
Issue number4
StatePublished - Oct 1995


  • Alcoholism
  • Depression
  • Frontal cortex
  • Human
  • Major depression
  • Neuropeptide Y
  • Suicide

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience


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