TY - JOUR
T1 - Neuroplasticity of language networks in aphasia
T2 - Advances, updates, and future challenges
AU - Kiran, Swathi
AU - Thompson, Cynthia K.
N1 - Funding Information:
This work was supported by the NIH/NIDCD Clinical Research Center Grant, P50DC012283 (PI: CT; Subproject 1 PI: SK; Subproject 3 PI: CT).
Publisher Copyright:
Copyright © 2019 Kiran and Thompson.
PY - 2019
Y1 - 2019
N2 - Researchers have sought to understand how language is processed in the brain, how brain damage affects language abilities, and what can be expected during the recovery period since the early 19th century. In this review, we first discuss mechanisms of damage and plasticity in the post-stroke brain, both in the acute and the chronic phase of recovery. We then review factors that are associated with recovery. First, we review organism intrinsic variables such as age, lesion volume and location and structural integrity that influence language recovery. Next, we review organism extrinsic factors such as treatment that influence language recovery. Here, we discuss recent advances in our understanding of language recovery and highlight recent work that emphasizes a network perspective of language recovery. Finally, we propose our interpretation of the principles of neuroplasticity, originally proposed by Kleim and Jones (1) in the context of extant literature in aphasia recovery and rehabilitation. Ultimately, we encourage researchers to propose sophisticated intervention studies that bring us closer to the goal of providing precision treatment for patients with aphasia and a better understanding of the neural mechanisms that underlie successful neuroplasticity.
AB - Researchers have sought to understand how language is processed in the brain, how brain damage affects language abilities, and what can be expected during the recovery period since the early 19th century. In this review, we first discuss mechanisms of damage and plasticity in the post-stroke brain, both in the acute and the chronic phase of recovery. We then review factors that are associated with recovery. First, we review organism intrinsic variables such as age, lesion volume and location and structural integrity that influence language recovery. Next, we review organism extrinsic factors such as treatment that influence language recovery. Here, we discuss recent advances in our understanding of language recovery and highlight recent work that emphasizes a network perspective of language recovery. Finally, we propose our interpretation of the principles of neuroplasticity, originally proposed by Kleim and Jones (1) in the context of extant literature in aphasia recovery and rehabilitation. Ultimately, we encourage researchers to propose sophisticated intervention studies that bring us closer to the goal of providing precision treatment for patients with aphasia and a better understanding of the neural mechanisms that underlie successful neuroplasticity.
KW - Aphasia
KW - Neuroimaging (anatomic and functional)
KW - Plasticity
KW - Recovery
KW - Stroke
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U2 - 10.3389/fneur.2019.00295
DO - 10.3389/fneur.2019.00295
M3 - Review article
C2 - 31001187
AN - SCOPUS:85067878002
VL - 10
JO - Frontiers in Neurology
JF - Frontiers in Neurology
SN - 1664-2295
IS - APR
M1 - 295
ER -