Abstract
Ischemic stroke causes brain infarction and neurological deficits. Along with these pathological changes, ischemic stroke also activates neuroprotective mechanisms that mitigate brain injury. It has long been recognized that the ischemic brain can upregulate neuroprotective genes to support neuronal survival. The present investigation demonstrated that, in addition to the ischemic brain, the liver was able to respond to ischemic stroke to upregulate genes encoding secreted neuroprotective proteins, including fibroblast growth factor 21 (FGF21), resistin-like molecule? (RELM?), and trefoil factor 3 (TFF3). These proteins access the ischemic brain via the circulation to protect ischemic neurons from injury. This report shows how these liver-derived neuroprotective genes were identified by transcriptomic analysis and neuroprotective protein screening.
| Original language | English (US) |
|---|---|
| Title of host publication | 2017 2nd IEEE International Conference on Computational Intelligence and Applications, ICCIA 2017 |
| Publisher | Institute of Electrical and Electronics Engineers Inc. |
| Pages | 387-391 |
| Number of pages | 5 |
| ISBN (Electronic) | 9781538620304 |
| DOIs | |
| State | Published - Dec 4 2017 |
| Event | 2nd IEEE International Conference on Computational Intelligence and Applications, ICCIA 2017 - Beijing, China Duration: Sep 8 2017 → Sep 11 2017 |
Publication series
| Name | 2017 2nd IEEE International Conference on Computational Intelligence and Applications, ICCIA 2017 |
|---|---|
| Volume | 2017-January |
Other
| Other | 2nd IEEE International Conference on Computational Intelligence and Applications, ICCIA 2017 |
|---|---|
| Country | China |
| City | Beijing |
| Period | 9/8/17 → 9/11/17 |
Fingerprint
Keywords
- FGF21
- Ischemic stroke
- Liver
- RELMγ
- Systems neuroprotective mechanisms
- TFF3
ASJC Scopus subject areas
- Artificial Intelligence
- Computer Science Applications
Cite this
}
Neuroprotective genes activated in the liver in response to experimental stroke. / Liu, Shu Qian; Shah, Sahil V.; Wu, Yu H.
2017 2nd IEEE International Conference on Computational Intelligence and Applications, ICCIA 2017. Institute of Electrical and Electronics Engineers Inc., 2017. p. 387-391 (2017 2nd IEEE International Conference on Computational Intelligence and Applications, ICCIA 2017; Vol. 2017-January).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
TY - GEN
T1 - Neuroprotective genes activated in the liver in response to experimental stroke
AU - Liu, Shu Qian
AU - Shah, Sahil V.
AU - Wu, Yu H.
PY - 2017/12/4
Y1 - 2017/12/4
N2 - Ischemic stroke causes brain infarction and neurological deficits. Along with these pathological changes, ischemic stroke also activates neuroprotective mechanisms that mitigate brain injury. It has long been recognized that the ischemic brain can upregulate neuroprotective genes to support neuronal survival. The present investigation demonstrated that, in addition to the ischemic brain, the liver was able to respond to ischemic stroke to upregulate genes encoding secreted neuroprotective proteins, including fibroblast growth factor 21 (FGF21), resistin-like molecule? (RELM?), and trefoil factor 3 (TFF3). These proteins access the ischemic brain via the circulation to protect ischemic neurons from injury. This report shows how these liver-derived neuroprotective genes were identified by transcriptomic analysis and neuroprotective protein screening.
AB - Ischemic stroke causes brain infarction and neurological deficits. Along with these pathological changes, ischemic stroke also activates neuroprotective mechanisms that mitigate brain injury. It has long been recognized that the ischemic brain can upregulate neuroprotective genes to support neuronal survival. The present investigation demonstrated that, in addition to the ischemic brain, the liver was able to respond to ischemic stroke to upregulate genes encoding secreted neuroprotective proteins, including fibroblast growth factor 21 (FGF21), resistin-like molecule? (RELM?), and trefoil factor 3 (TFF3). These proteins access the ischemic brain via the circulation to protect ischemic neurons from injury. This report shows how these liver-derived neuroprotective genes were identified by transcriptomic analysis and neuroprotective protein screening.
KW - FGF21
KW - Ischemic stroke
KW - Liver
KW - RELMγ
KW - Systems neuroprotective mechanisms
KW - TFF3
UR - http://www.scopus.com/inward/record.url?scp=85043453162&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85043453162&partnerID=8YFLogxK
U2 - 10.1109/CIAPP.2017.8167245
DO - 10.1109/CIAPP.2017.8167245
M3 - Conference contribution
T3 - 2017 2nd IEEE International Conference on Computational Intelligence and Applications, ICCIA 2017
SP - 387
EP - 391
BT - 2017 2nd IEEE International Conference on Computational Intelligence and Applications, ICCIA 2017
PB - Institute of Electrical and Electronics Engineers Inc.
ER -