Neuroprotective genes activated in the liver in response to experimental stroke

Shu Qian Liu, Sahil V. Shah, Yu H. Wu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Ischemic stroke causes brain infarction and neurological deficits. Along with these pathological changes, ischemic stroke also activates neuroprotective mechanisms that mitigate brain injury. It has long been recognized that the ischemic brain can upregulate neuroprotective genes to support neuronal survival. The present investigation demonstrated that, in addition to the ischemic brain, the liver was able to respond to ischemic stroke to upregulate genes encoding secreted neuroprotective proteins, including fibroblast growth factor 21 (FGF21), resistin-like molecule? (RELM?), and trefoil factor 3 (TFF3). These proteins access the ischemic brain via the circulation to protect ischemic neurons from injury. This report shows how these liver-derived neuroprotective genes were identified by transcriptomic analysis and neuroprotective protein screening.

Original languageEnglish (US)
Title of host publication2017 2nd IEEE International Conference on Computational Intelligence and Applications, ICCIA 2017
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages387-391
Number of pages5
ISBN (Electronic)9781538620304
DOIs
StatePublished - Dec 4 2017
Event2nd IEEE International Conference on Computational Intelligence and Applications, ICCIA 2017 - Beijing, China
Duration: Sep 8 2017Sep 11 2017

Publication series

Name2017 2nd IEEE International Conference on Computational Intelligence and Applications, ICCIA 2017
Volume2017-January

Other

Other2nd IEEE International Conference on Computational Intelligence and Applications, ICCIA 2017
CountryChina
CityBeijing
Period9/8/179/11/17

Fingerprint

Liver
Brain
Genes
Proteins
Gene encoding
Fibroblasts
Neurons
Screening
Molecules

Keywords

  • FGF21
  • Ischemic stroke
  • Liver
  • RELMγ
  • Systems neuroprotective mechanisms
  • TFF3

ASJC Scopus subject areas

  • Artificial Intelligence
  • Computer Science Applications

Cite this

Liu, S. Q., Shah, S. V., & Wu, Y. H. (2017). Neuroprotective genes activated in the liver in response to experimental stroke. In 2017 2nd IEEE International Conference on Computational Intelligence and Applications, ICCIA 2017 (pp. 387-391). (2017 2nd IEEE International Conference on Computational Intelligence and Applications, ICCIA 2017; Vol. 2017-January). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/CIAPP.2017.8167245
Liu, Shu Qian ; Shah, Sahil V. ; Wu, Yu H. / Neuroprotective genes activated in the liver in response to experimental stroke. 2017 2nd IEEE International Conference on Computational Intelligence and Applications, ICCIA 2017. Institute of Electrical and Electronics Engineers Inc., 2017. pp. 387-391 (2017 2nd IEEE International Conference on Computational Intelligence and Applications, ICCIA 2017).
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abstract = "Ischemic stroke causes brain infarction and neurological deficits. Along with these pathological changes, ischemic stroke also activates neuroprotective mechanisms that mitigate brain injury. It has long been recognized that the ischemic brain can upregulate neuroprotective genes to support neuronal survival. The present investigation demonstrated that, in addition to the ischemic brain, the liver was able to respond to ischemic stroke to upregulate genes encoding secreted neuroprotective proteins, including fibroblast growth factor 21 (FGF21), resistin-like molecule? (RELM?), and trefoil factor 3 (TFF3). These proteins access the ischemic brain via the circulation to protect ischemic neurons from injury. This report shows how these liver-derived neuroprotective genes were identified by transcriptomic analysis and neuroprotective protein screening.",
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Liu, SQ, Shah, SV & Wu, YH 2017, Neuroprotective genes activated in the liver in response to experimental stroke. in 2017 2nd IEEE International Conference on Computational Intelligence and Applications, ICCIA 2017. 2017 2nd IEEE International Conference on Computational Intelligence and Applications, ICCIA 2017, vol. 2017-January, Institute of Electrical and Electronics Engineers Inc., pp. 387-391, 2nd IEEE International Conference on Computational Intelligence and Applications, ICCIA 2017, Beijing, China, 9/8/17. https://doi.org/10.1109/CIAPP.2017.8167245

Neuroprotective genes activated in the liver in response to experimental stroke. / Liu, Shu Qian; Shah, Sahil V.; Wu, Yu H.

2017 2nd IEEE International Conference on Computational Intelligence and Applications, ICCIA 2017. Institute of Electrical and Electronics Engineers Inc., 2017. p. 387-391 (2017 2nd IEEE International Conference on Computational Intelligence and Applications, ICCIA 2017; Vol. 2017-January).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Liu SQ, Shah SV, Wu YH. Neuroprotective genes activated in the liver in response to experimental stroke. In 2017 2nd IEEE International Conference on Computational Intelligence and Applications, ICCIA 2017. Institute of Electrical and Electronics Engineers Inc. 2017. p. 387-391. (2017 2nd IEEE International Conference on Computational Intelligence and Applications, ICCIA 2017). https://doi.org/10.1109/CIAPP.2017.8167245