@inproceedings{852c60fbcb00481888b272becb85a67d,
title = "Neuroprotective genes activated in the liver in response to experimental stroke",
abstract = "Ischemic stroke causes brain infarction and neurological deficits. Along with these pathological changes, ischemic stroke also activates neuroprotective mechanisms that mitigate brain injury. It has long been recognized that the ischemic brain can upregulate neuroprotective genes to support neuronal survival. The present investigation demonstrated that, in addition to the ischemic brain, the liver was able to respond to ischemic stroke to upregulate genes encoding secreted neuroprotective proteins, including fibroblast growth factor 21 (FGF21), resistin-like molecule? (RELM?), and trefoil factor 3 (TFF3). These proteins access the ischemic brain via the circulation to protect ischemic neurons from injury. This report shows how these liver-derived neuroprotective genes were identified by transcriptomic analysis and neuroprotective protein screening.",
keywords = "FGF21, Ischemic stroke, Liver, RELMγ, Systems neuroprotective mechanisms, TFF3",
author = "Liu, \{Shu Q.\} and Shah, \{Sahil V.\} and Wu, \{Yu H.\}",
note = "Publisher Copyright: {\textcopyright} 2017 IEEE.; 2nd IEEE International Conference on Computational Intelligence and Applications, ICCIA 2017 ; Conference date: 08-09-2017 Through 11-09-2017",
year = "2017",
month = dec,
day = "4",
doi = "10.1109/CIAPP.2017.8167245",
language = "English (US)",
series = "2017 2nd IEEE International Conference on Computational Intelligence and Applications, ICCIA 2017",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "387--391",
booktitle = "2017 2nd IEEE International Conference on Computational Intelligence and Applications, ICCIA 2017",
address = "United States",
}
