Neuropsychological assessment as an objective tool to monitor treatment response in anti-N-methyl-D-aspartate receptor encephalitis

Erica Sieg, Michael Brook, Jenny Linnoila, Stephen Vanhaerents*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

We report a 1-year follow-up of a young woman with anti-N-methyl-D-aspartate receptor encephalitis. Management of autoimmune encephalitis remains challenging as objective and clinically relevant biomarkers are sought, which allow for the monitoring of treatment response. While further investigation is required, we believe that this case highlights the importance of following a comprehensive neuropsychological profile as a clinically relevant biomarker to guide therapeutic decision-making. By relying on the neuropsychological assessment of the patient, treatment with more toxic medications was avoided and her antiepileptic drug regimen was simplified.

Original languageEnglish (US)
Article numberbcr-2018-224169
JournalBMJ Case Reports
Volume2018
DOIs
StatePublished - Jan 1 2018

Fingerprint

Anti-N-Methyl-D-Aspartate Receptor Encephalitis
Biomarkers
Poisons
Anticonvulsants
Decision Making
Therapeutics

Keywords

  • clinical neurophysiology
  • epilepsy and seizures
  • immunology
  • memory disorders (psychiatry)

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{5792d1cde8554797aae8030b81179a17,
title = "Neuropsychological assessment as an objective tool to monitor treatment response in anti-N-methyl-D-aspartate receptor encephalitis",
abstract = "We report a 1-year follow-up of a young woman with anti-N-methyl-D-aspartate receptor encephalitis. Management of autoimmune encephalitis remains challenging as objective and clinically relevant biomarkers are sought, which allow for the monitoring of treatment response. While further investigation is required, we believe that this case highlights the importance of following a comprehensive neuropsychological profile as a clinically relevant biomarker to guide therapeutic decision-making. By relying on the neuropsychological assessment of the patient, treatment with more toxic medications was avoided and her antiepileptic drug regimen was simplified.",
keywords = "clinical neurophysiology, epilepsy and seizures, immunology, memory disorders (psychiatry)",
author = "Erica Sieg and Michael Brook and Jenny Linnoila and Stephen Vanhaerents",
year = "2018",
month = "1",
day = "1",
doi = "10.1136/bcr-2018-224169",
language = "English (US)",
volume = "2018",
journal = "BMJ Case Reports",
issn = "1757-790X",
publisher = "BMJ Publishing Group",

}

Neuropsychological assessment as an objective tool to monitor treatment response in anti-N-methyl-D-aspartate receptor encephalitis. / Sieg, Erica; Brook, Michael; Linnoila, Jenny; Vanhaerents, Stephen.

In: BMJ Case Reports, Vol. 2018, bcr-2018-224169, 01.01.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Neuropsychological assessment as an objective tool to monitor treatment response in anti-N-methyl-D-aspartate receptor encephalitis

AU - Sieg, Erica

AU - Brook, Michael

AU - Linnoila, Jenny

AU - Vanhaerents, Stephen

PY - 2018/1/1

Y1 - 2018/1/1

N2 - We report a 1-year follow-up of a young woman with anti-N-methyl-D-aspartate receptor encephalitis. Management of autoimmune encephalitis remains challenging as objective and clinically relevant biomarkers are sought, which allow for the monitoring of treatment response. While further investigation is required, we believe that this case highlights the importance of following a comprehensive neuropsychological profile as a clinically relevant biomarker to guide therapeutic decision-making. By relying on the neuropsychological assessment of the patient, treatment with more toxic medications was avoided and her antiepileptic drug regimen was simplified.

AB - We report a 1-year follow-up of a young woman with anti-N-methyl-D-aspartate receptor encephalitis. Management of autoimmune encephalitis remains challenging as objective and clinically relevant biomarkers are sought, which allow for the monitoring of treatment response. While further investigation is required, we believe that this case highlights the importance of following a comprehensive neuropsychological profile as a clinically relevant biomarker to guide therapeutic decision-making. By relying on the neuropsychological assessment of the patient, treatment with more toxic medications was avoided and her antiepileptic drug regimen was simplified.

KW - clinical neurophysiology

KW - epilepsy and seizures

KW - immunology

KW - memory disorders (psychiatry)

UR - http://www.scopus.com/inward/record.url?scp=85048592972&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048592972&partnerID=8YFLogxK

U2 - 10.1136/bcr-2018-224169

DO - 10.1136/bcr-2018-224169

M3 - Article

VL - 2018

JO - BMJ Case Reports

JF - BMJ Case Reports

SN - 1757-790X

M1 - bcr-2018-224169

ER -