Neuropsychological patterns and language deficits in 20 consecutive cases of autopsy-confirmed alzheimer's disease

Bruce H. Price*, Sandra Weintraub, Changiz Geula, Elizabeth Leimkuhler, Marsel Mesulam, Hakan Gurvit

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

135 Scopus citations


A retrospective chart review of clinical symptoms was done for 20 consecutive patients in whom postmortem examination had revealed senile plaques and neurofibrillary tangles in a distribution consistent with Alzheimer's disease. All patients had met clinical diagnostic criteria for probable Alzheimer's disease. On initial examination, 1 to 14 years beyond putative onset of the dementia, all patients displayed at least some memory impairment. In 16 patients, disturbances of attention or recent memory were among the most salient features. In two patients, language disturbances, and in two others, visuospatial deficits, were more prominent than difficulties with memory and attention. On initial examination, 17 of the 20 patients displayed word-finding difficulties, characteristically in the context of a fluent, anomic aphasia. All of the 12 reexamined patients demonstrated progressive, although variable, deterioration. In general, the initial salient deficit remained salient during much of the disease course. Language comprehension was spared in the earlier stages but eventually deteriorated. Severe deficits emerged in all major cognitive domains as the disease reached the terminal stages. Nonfluent aphasias (eg, Broca's aphasia) were not observed even in the advanced stages of the disease.

Original languageEnglish (US)
Pages (from-to)931-937
Number of pages7
JournalArchives of Neurology
Issue number9
StatePublished - Sep 1993

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)


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