Neuropsychologie deficits in schizophrenia: Relation to social function and effect of antipsychotic drug treatment

Herbert Y. Meitzer*, Paul A. Thompson, Myung A. Lee, Rakesh Ranjan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

127 Scopus citations

Abstract

Cognitive impairment is present in the majority of schizophrenic patients, even at the onset of psychosis. It is a relatively stable characteristic in most patients, usually with little progression over the course of illness, but sometimes progresses to severe dementia. The results of studies of the effects of typical neuroleptic drugs on cognitive functioning in schizophrenia are conflicting. Clozapine, which has superior antipsychotic effects compared to typical neuroleptic drugs, has been reported to improve executive function, verbal fluency, attention, and recall memory in two of three studies. Cognitive measures predict work function and overall outcome on clozapine as assessed by the Global Assessment Scale and Quality-of-Life Scale in neuroleptic-resistant schizophrenia. Improvement in cognitive function by clozapine may be a major reason for expanding its currently limited utilization. [Neuropsychopharmacology 14:27S-33S, 1996].

Original languageEnglish (US)
Pages (from-to)27s-33s
JournalNeuropsychopharmacology
Volume14
DOIs
StatePublished - Mar 1996

Keywords

  • Cognitive function
  • Neuroleptic
  • Quality of life
  • Schizophrenia

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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