Neurotensin activates tuberoinfundibular dopamine neurons and increases serum corticosterone concentrations in the rat

G. A. Gudelsky, S. A. Berry, H. Y. Meltzer

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

The activity of tuberoinfundibular dopamine neurons, as estimated from the amount of dihydroxyphenylalanine (DOPA) formed in the median eminence after the inhibition of DOPA decarboxylase and the concentration of dihydroxyphenylacetic acid (DOPAC) in this brain region, was significantly increased 1-8 h following the intracerebroventricular (i.c.v.) administration of neurotensin (20 μg). Neurotensin (5 and 20 μg i.c.v.) also significantly increased DOPAC concentrations in the n. accumbens but had no effect in the striatum. Serum concentrations of corticosterone in rats treated with neurotensin (1-20 μg i.c.v.) were 5-7 times those in vehicle-treated animals. [D-Trp11]-neurotensin (0.5 μg i.c.v.) also significantly increased DOPAC concentrations in the median eminence and serum corticosterone concentrations. It is concluded that neurotensin acutely increases the activity of tuberoinfundibular and mesolimbic dopamine neurons and the secretion of ACTH.

Original languageEnglish (US)
Pages (from-to)604-609
Number of pages6
JournalNeuroendocrinology
Volume49
Issue number6
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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