Neurotoxicity of antiretroviral therapy

Charles T. Upton; Babafemi O Taiwo; Kevin R. Robertson

doi:10.2217/fvl.13.30

Neurotoxicity of antiretroviral therapy

Charles T. Upton^*, Babafemi O Taiwo, Kevin R. Robertson

^*Corresponding author for this work

Medicine, Infectious Diseases Division

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

The neurological outcome of HIV infection has changed dramatically in the era of HAART. Despite effective suppression of plasma viral load and a substantial decrease in the incidence of HIV-associated dementia, neurocognitive impairment and peripheral neuropathy remain widespread. The neurotoxic side effects of antiretroviral (ARV) agents are among several contributing factors to this continued prevalence. Effective penetration of the CNS by ARV agents is paramount to treating neurological symptoms as well as systemic infection, but may also exacerbate the severity of drug-related neurotoxicity. The neurotoxic side effects of ARV agents vary widely between and within drug classes. The risks and benefits of combination regimens continue to evolve as more effective treatment protocols are developed.

Original language	English (US)
Pages (from-to)	469-475
Number of pages	7
Journal	Future Virology
Volume	8
Issue number	5
DOIs	https://doi.org/10.2217/fvl.13.30
State	Published - May 1 2013

Keywords

CNS penetration effectiveness
HIV
HIV-associated neurocognitive disorders
antiretroviral therapy
inflammation
neurotoxicity
peripheral neuropathy

ASJC Scopus subject areas

Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/fvl.13.30

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title = "Neurotoxicity of antiretroviral therapy",

abstract = "The neurological outcome of HIV infection has changed dramatically in the era of HAART. Despite effective suppression of plasma viral load and a substantial decrease in the incidence of HIV-associated dementia, neurocognitive impairment and peripheral neuropathy remain widespread. The neurotoxic side effects of antiretroviral (ARV) agents are among several contributing factors to this continued prevalence. Effective penetration of the CNS by ARV agents is paramount to treating neurological symptoms as well as systemic infection, but may also exacerbate the severity of drug-related neurotoxicity. The neurotoxic side effects of ARV agents vary widely between and within drug classes. The risks and benefits of combination regimens continue to evolve as more effective treatment protocols are developed.",

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AU - Upton, Charles T.

AU - Taiwo, Babafemi O

AU - Robertson, Kevin R.

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N2 - The neurological outcome of HIV infection has changed dramatically in the era of HAART. Despite effective suppression of plasma viral load and a substantial decrease in the incidence of HIV-associated dementia, neurocognitive impairment and peripheral neuropathy remain widespread. The neurotoxic side effects of antiretroviral (ARV) agents are among several contributing factors to this continued prevalence. Effective penetration of the CNS by ARV agents is paramount to treating neurological symptoms as well as systemic infection, but may also exacerbate the severity of drug-related neurotoxicity. The neurotoxic side effects of ARV agents vary widely between and within drug classes. The risks and benefits of combination regimens continue to evolve as more effective treatment protocols are developed.

AB - The neurological outcome of HIV infection has changed dramatically in the era of HAART. Despite effective suppression of plasma viral load and a substantial decrease in the incidence of HIV-associated dementia, neurocognitive impairment and peripheral neuropathy remain widespread. The neurotoxic side effects of antiretroviral (ARV) agents are among several contributing factors to this continued prevalence. Effective penetration of the CNS by ARV agents is paramount to treating neurological symptoms as well as systemic infection, but may also exacerbate the severity of drug-related neurotoxicity. The neurotoxic side effects of ARV agents vary widely between and within drug classes. The risks and benefits of combination regimens continue to evolve as more effective treatment protocols are developed.

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KW - HIV

KW - HIV-associated neurocognitive disorders

KW - antiretroviral therapy

KW - inflammation

KW - neurotoxicity

KW - peripheral neuropathy

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Neurotoxicity of antiretroviral therapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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