Neurovascular fibrinolytic activity in normal Lewis rats and rats with cell-transferred experimental allergic encephalomyelitis

Chang Sung Koh*, Hau C. Kwaan, Philip Y. Paterson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Fibrinolytic activity in the form of plasminogen activator (PA) was assessed using a histochemical fibrin slide technique in spinal cords of normal Lewis rats and rats with the cell-transferred from of experimental allergic encephalomyelitis (EAE). PA was localized exclusively to blood vessels. Vessels in the leptomeninges had maximum activity. A precipitous decrease in PA activity occured in recipient rats which coincided with onset of clinical neurologic signs. A subsequent return in activity occured in association with clinical remission of disease but remained well below the activity of normal rats for as long as the recipient animals were followed. Vessels containing perivascular cellular infiltrates of EAE had little or no detectable PA activity. Furthermore, PA could not be demonstrated to be associated with infiltrating inflammatory cells, including macrophages. These findings provide further support for involvement of the coagulation and fibrinolytic ssytems in the early clinical manifestation of EAE in Lewis rats.

Original languageEnglish (US)
Pages (from-to)189-200
Number of pages12
JournalJournal of Neuroimmunology
Volume28
Issue number3
DOIs
StatePublished - Aug 1990

Keywords

  • Experimental allergic encephalomyelitis
  • Fibrinolysis
  • Plasminogen activator

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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