Neutrophil chemotaxis, phagocytosis, and superoxide release in depressive illness

Michael Maes*, Wim Stevens, Luc DeClerck, Dirk Peeters, Chris Bridts, Chris Schote, Herbert Meltzer, Simon Scharpé, Paul Cosyns

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Recently, some authors have reported defective neutrophil phagocytosis during depression. The present study investigated neutrophil function in 19 healthy controls and in 41 depressed inpatients categorized according to DSM-III into minor, simple major, and melancholic depression. We determined neutrophil function by means of phagocytosis, chemotaxis, and superoxide release. The results show no significant differences in neutrophil function among any of the subtypes of depression and normal volunteers. This suggests that overall neutrophil function is normal during depression. Thus, neutrophils are unlikely to be involved in the increased susceptibility to physical illness of patients with depression.

Original languageEnglish (US)
Pages (from-to)1220-1224
Number of pages5
JournalBiological psychiatry
Issue number12
StatePublished - Jun 15 1992

ASJC Scopus subject areas

  • Biological Psychiatry

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