Neutrophil gelatinase-associated lipocalin as a biomarker of disease activity in pediatric lupus nephritis

Michiko Suzuki, Kristina M. Wiers, Marisa S. Klein-Gitelman, Kathleen A. Haines, Judyann Olson, Karen B. Onel, Kathleen O'Neil, Murray H. Passo, Nora G. Singer, Lori Tucker, Jun Ying, Prasad Devarajan, Hermine I. Brunner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

104 Scopus citations

Abstract

We hypothesized that neutrophil gelatinase-associated lipocalin (NGAL) is an early predictive biomarker of disease activity in lupus nephritis. NGAL in serial plasma (PNGAL) and urine (UNGAL) samples was measured by enzyme-linked immunosorbent assay (ELISA) in 85 participants with pediatric systemic lupus erythematosus (pSLE), healthy children (n=50), and children with juvenile idiopathic arthritis (JIA) (n=30). Disease activity was measured by the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Plasma and urinary NGAL were significantly increased in subjects with pSLE compared with those with JIA or with healthy controls (all p<0.03), and unrelated to subjects' age, weight, or height. Plasma and urinary NGAL were stable in pSLE subjects with unchanged disease activity. The pSLE subjects with worsening global or renal disease activity had a mean ± standard error (SE) increase of UNGAL (in ng/ml) of 11.5±6.4 or 36.6±12.1 (p<0.01), corresponding to a 156% or 380% increase, respectively. PNGAL increased with worsening disease but to a much lesser degree than UNGAL [global disease activity (mean±SE): 7.3±6.2 or 21%; renal disease activity: 20.2±6.0 or 51%; both p=not significant]. In conclusion, NGAL in urine but not in plasma represents a novel biomarker for renal disease activity in pSLE.

Original languageEnglish (US)
Pages (from-to)403-412
Number of pages10
JournalPediatric Nephrology
Volume23
Issue number3
DOIs
StatePublished - Mar 2008

Keywords

  • Biomarker
  • Lupus nephritis
  • NGAL
  • Pediatric SLE (pSLE)
  • Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)
  • Systemic lupus erythematosus (SLE)

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

Fingerprint Dive into the research topics of 'Neutrophil gelatinase-associated lipocalin as a biomarker of disease activity in pediatric lupus nephritis'. Together they form a unique fingerprint.

Cite this