Neutrophil trails guide influenzaspecific CD8+ T cells in the airways

Kihong Lim, Young Min Hyun, Kris Lambert-Emo, Tara Capece, Seyeon Bae, Richard Miller, David J. Topham, Minsoo Kim*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

182 Scopus citations

Abstract

During viral infections, chemokines guide activated effector T cells to infection sites. However, the cells responsible for producing these chemokines and how such chemokines recruit T cells are unknown. Here, we show that the early recruitment of neutrophils into influenza-infected trachea is essential for CD8+ T cell-mediated immune protection in mice. We observed that migrating neutrophils leave behind long-lasting trails that are enriched in the chemokine CXCL12. Experiments with granulocyte-specific CXCL12 conditionally depleted mice and a CXCR4 antagonist revealed that CXCL12 derived from neutrophil trails is critical for virus-specific CD8+ T cell recruitment and effector functions. Collectively, these results suggest that neutrophils deposit long-lasting, chemokinecontaining trails, which may provide both chemotactic and haptotactic cues for efficient CD8+ T cell migration and localization in influenza-infected tissues.

Original languageEnglish (US)
Article number1071
JournalScience
Volume349
Issue number6252
DOIs
StatePublished - Sep 4 2015

ASJC Scopus subject areas

  • General

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