Abstract
We describe a case of nevirapine-induced Stevens-Johnson Syndrome (SJS) and fulminant hepatic failure (FHF) requiring liver transplantation. Five weeks prior to admission, a 57-year-old female with HIV infection had been switched to a nevirapine-based regimen of highly active antiretroviral therapy (HAART) with a CD4 cell count of 695/mm3. Examination of the explanted native liver at initial transplantation revealed massive hepatic necrosis consistent with drug-induced liver injury. Primary graft nonfunction complicated the early postoperative course and liver retransplantation was required. On follow-up 2 years later, she remains in good health with an undetectable viral load on an efavirenz-based regimen of HAART. To our knowledge, this is the first report of successful liver transplantation following SJS and FHF.
Original language | English (US) |
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Pages (from-to) | 1713-1716 |
Number of pages | 4 |
Journal | American Journal of Transplantation |
Volume | 10 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2010 |
Keywords
- Hepatotoxicity
- Stevens-Johnson syndrome
- liver
- nevirapine
- transplant
ASJC Scopus subject areas
- Transplantation
- Pharmacology (medical)
- Immunology and Allergy