Nevirapine-induced Stevens Johnson-syndrome and fulminant hepatic failure requiring liver transplantation

J. Jao*, M. Sturdevant, J. Del Rio Martin, T. Schiano, M. I. Fiel, S. Huprikar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

We describe a case of nevirapine-induced Stevens-Johnson Syndrome (SJS) and fulminant hepatic failure (FHF) requiring liver transplantation. Five weeks prior to admission, a 57-year-old female with HIV infection had been switched to a nevirapine-based regimen of highly active antiretroviral therapy (HAART) with a CD4 cell count of 695/mm3. Examination of the explanted native liver at initial transplantation revealed massive hepatic necrosis consistent with drug-induced liver injury. Primary graft nonfunction complicated the early postoperative course and liver retransplantation was required. On follow-up 2 years later, she remains in good health with an undetectable viral load on an efavirenz-based regimen of HAART. To our knowledge, this is the first report of successful liver transplantation following SJS and FHF.

Original languageEnglish (US)
Pages (from-to)1713-1716
Number of pages4
JournalAmerican Journal of Transplantation
Volume10
Issue number7
DOIs
StatePublished - Jul 2010

Keywords

  • Hepatotoxicity
  • Stevens-Johnson syndrome
  • liver
  • nevirapine
  • transplant

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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