Abstract
A series of halo- and nitro-substituted analogues of N-(2-aminoethyl)benzamide has been synthesized. All of the compounds are competitive, time-dependent inhibitors of monoamine oxidase-B (MAO-B), but upon dialysis complete return of enzyme activity is observed for all compounds. Therefore, these are mechanism-based reversible inhibitors of MAO-B. The relative potencies of the compounds are rationalized in terms of steric and hydrophobic effects.
Original language | English (US) |
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Pages (from-to) | 3968-3970 |
Number of pages | 3 |
Journal | Journal of Medicinal Chemistry |
Volume | 36 |
Issue number | 24 |
DOIs |
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State | Published - 1993 |
ASJC Scopus subject areas
- Drug Discovery
- Molecular Medicine