New and emerging risk factors for coronary heart disease

Ehimare Akhabue, Jeffrey Thiboutot, Jeh Wei Cheng, Timothy J. Vittorio, Georgios Christodoulidis, Kathleen M. Grady, Stamatios Lerakis*, Constantine E. Kosmas

*Corresponding author for this work

Research output: Contribution to journalReview article

22 Scopus citations


Coronary heart disease (CHD) is one of the leading causes of death in the United States. Traditional risk factors such as family history, hypertension, hypercholesterolemia, diabetes mellitus and smoking cannot account for the entire risk for incident coronary events. Several other potential risk factors have been identified in an effort to improve risk assessment for CHD. This article reviews the current evidence on new and emerging risk factors for CHD and their current utility in screening, specifically focusing on coronary artery calcium score, C-reactive protein, lipoprotein (a), carotid intima-media thickness, homocysteine, lipoprotein-associated phospholipase A2, as well as high-density lipoprotein functionality.

Original languageEnglish (US)
Pages (from-to)151-158
Number of pages8
JournalAmerican Journal of the Medical Sciences
Issue number2
StatePublished - Jan 1 2014


  • C-reactive protein
  • Carotid intimal media thickness
  • Coronary artery calcium score
  • Coronary heart disease
  • Lipoprotein (a)

ASJC Scopus subject areas

  • Medicine(all)

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    Akhabue, E., Thiboutot, J., Cheng, J. W., Vittorio, T. J., Christodoulidis, G., Grady, K. M., Lerakis, S., & Kosmas, C. E. (2014). New and emerging risk factors for coronary heart disease. American Journal of the Medical Sciences, 347(2), 151-158.