New Approaches to Glioblastoma

Mustafa Khasraw, Yoko Fujita, Catalina Lee-Chang, Irina V. Balyasnikova, Hinda Najem, Amy B. Heimberger

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Faced with unique immunobiology and marked heterogeneity, treatment strategies for glioblastoma require therapeutic approaches that diverge from conventional oncological strategies. The selection and prioritization of targeted and immunotherapeutic strategies will need to carefully consider these features and companion biomarkers developed alongside treatment strategies to identify the appropriate patient populations. Novel clinical trial strategies that interrogate the tumor microenvironment for drug penetration and target engagement will inform go/no-go later-stage clinical studies. Innovative trial designs and analyses are needed to move effective agents toward regulatory approvals more rapidly.

Original languageEnglish (US)
Pages (from-to)279-292
Number of pages14
JournalAnnual review of medicine
Volume73
DOIs
StatePublished - 2022

Keywords

  • Glioblastoma
  • Immunotherapy
  • Precision medicine

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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