New concepts in the pathogenesis of urinary tract infections

Anthony J. Schaeffer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Random amplified polymorphic DNA fingerprinting was used to distinguish among Escherichia coli bacterial strains creating urinary tract infections (UTIs) in women. Bacteria bound more avidly to cells from postmenopausal donors with history of UTIs (PK) compared with cells from women without history of UTIs (AO). Nonpiliated bacterial strains did not adhere to the cell lines. Increasing S-IgA concentrations has no effect on AO cell bacterial binding, whereas bacterial adhesion to PK cell epithelium increased with increasing S-IgA concentration.

Original languageEnglish (US)
Pages (from-to)241-250
Number of pages10
JournalUrologic Clinics of North America
Issue number1
StatePublished - Jul 17 2002

ASJC Scopus subject areas

  • Urology


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