New directions in thrombolytic therapy. Molecular mutants and biochemical conjugates

Douglas E. Vaughan*, Joseph Loscalzo

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

3 Scopus citations

Abstract

The currently available thrombolytic agents are widely perceived to be suboptimal in terms of both efficacy and safety. This perception has in turn stimulated efforts to design and construct novel plasminogen activators endowed with improved biochemical and pharmacologic properties. There is as yet no consensus as to the properties of an "ideal" thrombolytic agent, and the failure of comparative clinical trials to identify a superior agent has contributed to the controversy. Although an improved plasminogen activator has not yet been constructed, it is clear that efforts to do so have advanced our knowledge of the complex structure-function relationships within plasminogen activators.

Original languageEnglish (US)
Pages (from-to)36-39
Number of pages4
JournalTrends in Cardiovascular Medicine
Volume1
Issue number1
DOIs
StatePublished - 1991

Funding

This work was supported by grants HL40411 and HL43344 from the Na tional Institutes of Health . Douglas E . Vaughan is the recipient of a Clinician-Scientist Award from the American Heart Association, Dallas, Texas, and a Research Advisory Group Award from the Veterans Administration . Joseph Loscalzo is the recipient of a Research Career Development Award (K04HL02273) from the National Institutes of Health and a Research Advisory Group Award from the Veterans Administration . The authors wish to thank Ms . S . Tribuna for excellent secretarial support .

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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