New insights into the pathogenesis of cellular crescents

Sunita K. Singh, Marie Jeansson, Susan E. Quaggin

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

Purpose of review: This review discusses the recent evidence that intrinsic glomerular cells including podocytes, parietal epithelial cells and progenitor cells within BowmanÊs capsule contribute to cellular crescents. Recent findings: Using a variety of newer molecular markers and lineage tracing experiments, investigators have clearly demonstrated that glomerular cells play a key role in the development and progression of cellular crescents in experimental and human disease. Summary: Crescentic glomerulonephritis is associated with significant morbidity and mortality. Current therapies target the immune system. The recent finding that nonimmune cells also play a role in crescent formation highlights the need to identify alternate and complimentary therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)258-262
Number of pages5
JournalCurrent opinion in nephrology and hypertension
Volume20
Issue number3
DOIs
StatePublished - May 1 2011

Keywords

  • cellular crescents
  • lineage tagging
  • parietal epithelial cells
  • podocytes
  • progenitor cells

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology

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