New magnetic resonance contrast agents as biochemical reporters

Thomas J Meade*, Alisha K. Taylor, Steven R. Bull

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

100 Scopus citations

Abstract

Magnetic resonance imaging is a noninvasive, volume rendering diagnostic technique that uses lanthanide complexes to enhance proton relaxation. Magnetic resonance imaging is not limited by light scattering as optical microscopic techniques are, and allows imaging of whole animals. Clinical contrast agents are nonspecific and report solely on anatomy, whereas contrast agents that can be activated can be tailored to report on the physiological status or metabolic activity of biological systems. These new classes of magnetic resonance contrast agents represent a substantial leap in the type of information that can be derived from imaging experiments, and are the focus of this review.

Original languageEnglish (US)
Pages (from-to)597-602
Number of pages6
JournalCurrent opinion in neurobiology
Volume13
Issue number5
DOIs
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • Neuroscience(all)

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