New-onset diabetes mellitus after heart transplantation in children – Incidence and risk factors

Swati Sehgal*, Matthew J. Bock, Hannah Louks Palac, Wendy Joy Brickman, Jeffrey G. Gossett, Bradley Scott Marino, Carl L Backer, Elfriede Pahl

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Diabetes mellitus is a recognized complication of SOT in adults and is associated with decreased graft and patient survival. Little is known about NOD in pediatric HT recipients. We aimed to characterize the incidence and describe risk factors for development of NOD after HT in children. Children who developed diabetes after HT were identified from the OPTN database. Demographic and clinical data before and after transplant were compared between patients with and without NOD. A total of 2056 children were included, 56% were male, 54% were Caucasian, and 62% had cardiomyopathy prior to HT. NOD developed in 219 children (11%) after HT. The incidence of NOD was 2.4, 9.0, and 10.4% at one, five, and 10 yr after HT, respectively. Obesity (HR: 4.32), dialysis prior to transplant (HR: 2.38), African American race (HR: 1.86), transplant before year 2000 (HR: 1.82), female gender (HR: 1.68), and older age at transplant (HR: 1.28) were independent predictors of NOD. The major modifiable risk factor for NOD is obesity, imparting the maximum hazard. Improved surveillance for diabetes in high-risk patients and specific prevention and intervention strategies are imperative in this population.

Original languageEnglish (US)
Pages (from-to)963-969
Number of pages7
JournalPediatric Transplantation
Volume20
Issue number7
DOIs
StatePublished - Nov 1 2016

Fingerprint

Heart Transplantation
Diabetes Mellitus
Transplants
Incidence
Obesity
Graft Survival
Cardiomyopathies
African Americans
Dialysis
Demography
Databases
Pediatrics
Population

Keywords

  • children
  • diabetes mellitus
  • heart transplantation
  • pediatric

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

Cite this

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title = "New-onset diabetes mellitus after heart transplantation in children – Incidence and risk factors",
abstract = "Diabetes mellitus is a recognized complication of SOT in adults and is associated with decreased graft and patient survival. Little is known about NOD in pediatric HT recipients. We aimed to characterize the incidence and describe risk factors for development of NOD after HT in children. Children who developed diabetes after HT were identified from the OPTN database. Demographic and clinical data before and after transplant were compared between patients with and without NOD. A total of 2056 children were included, 56{\%} were male, 54{\%} were Caucasian, and 62{\%} had cardiomyopathy prior to HT. NOD developed in 219 children (11{\%}) after HT. The incidence of NOD was 2.4, 9.0, and 10.4{\%} at one, five, and 10 yr after HT, respectively. Obesity (HR: 4.32), dialysis prior to transplant (HR: 2.38), African American race (HR: 1.86), transplant before year 2000 (HR: 1.82), female gender (HR: 1.68), and older age at transplant (HR: 1.28) were independent predictors of NOD. The major modifiable risk factor for NOD is obesity, imparting the maximum hazard. Improved surveillance for diabetes in high-risk patients and specific prevention and intervention strategies are imperative in this population.",
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New-onset diabetes mellitus after heart transplantation in children – Incidence and risk factors. / Sehgal, Swati; Bock, Matthew J.; Louks Palac, Hannah; Brickman, Wendy Joy; Gossett, Jeffrey G.; Marino, Bradley Scott; Backer, Carl L; Pahl, Elfriede.

In: Pediatric Transplantation, Vol. 20, No. 7, 01.11.2016, p. 963-969.

Research output: Contribution to journalArticle

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AU - Marino, Bradley Scott

AU - Backer, Carl L

AU - Pahl, Elfriede

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