New roles for the external globus pallidus in basal ganglia circuits and behavior

Aryn H. Gittis*, Joshua D. Berke, Mark D. Bevan, C. Savio Chan, Nicolas Mallet, Michelle M. Morrow, Robert Schmidt

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

93 Scopus citations


The development of methodology to identify specific cell populations and circuits within the basal ganglia is rapidly transforming our ability to understand the function of this complex circuit. This mini-symposium highlights recent advances in delineating the organization and function of neural circuits in the external segment of the globus pallidus (GPe). Although long considered a homogeneous structure in the motor-suppressing “indirect-pathway,” the GPe consists of a number of distinct cell types and anatomical subdomains that contribute differentially to both motor and nonmotor features of behavior. Here, we integrate recent studies using techniques, such as viral tracing, transgenic mice, electrophysiology, and behavioral approaches, to create a revised framework for understanding how the GPe relates to behavior in both health and disease.

Original languageEnglish (US)
Pages (from-to)15178-15183
Number of pages6
JournalJournal of Neuroscience
Issue number46
StatePublished - Nov 12 2014

ASJC Scopus subject areas

  • General Neuroscience


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