New roles for the RB tumor suppressor protein

Huiping Liu*, Benjamin Dibling, Benjamin Spike, Alexandra Dirlam, Kay Macleod

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

81 Scopus citations

Abstract

For a gene whose existence was first postulated in 1971, was cloned in 1986 and whose functions have been extensively characterized ever since, you might be inclined to think there was not much new to report regarding the retinoblastoma tumor suppressor gene (RB) - but you would be wrong to make such an assumption. RB is still piquing our interest with several activities defined over the past year that reveal new and exciting roles for this key tumor suppressor gene. These functions include regulation of senescence through specific gene silencing mechanisms, control of developmental processes in extra-embryonic tissues, maintaining tissue homeostasis and determining survival responses to chemotherapy.

Original languageEnglish (US)
Pages (from-to)55-64
Number of pages10
JournalCurrent Opinion in Genetics and Development
Volume14
Issue number1
DOIs
StatePublished - Feb 1 2004

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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