New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation

Matthew L. Arwood, Yao Liu, Shannon K. Harkins, David M. Weinstock, Lei Yang, Kristen E. Stevenson, Olivia D. Plana, Jingyun Dong, Haley Cirka, Kristen L. Jones, Anniina T. Virtanen, Dikshat G. Gupta, Amanda Ceas, Brian Lawney, Akinori Yoda, Catharine Leahy, Mingfeng Hao, Zhixiang He, Hwan Geun Choi, Yaning WangOlli Silvennoinen, Stevan R. Hubbard, Tinghu Zhang, Nathanael S. Gray*, Loretta S. Li*

*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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  • Crystal structure of JAK2 JH1 with type II inhibitor YLIU-04-105-1

    Arwood, M. L. (Contributor), Liu, Y. (Contributor), Harkins, S. K. (Contributor), Weinstock, D. M. (Contributor), Yang, L. (Contributor), Stevenson, K. E. (Contributor), Plana, O. D. (Contributor), Dong, J. (Contributor), Cirka, H. (Contributor), Jones, K. L. (Contributor), Virtanen, A. T. (Contributor), Gupta, D. G. (Contributor), Ceas, A. (Contributor), Lawney, B. (Contributor), Yoda, A. (Contributor), Leahy, C. (Contributor), Hao, M. (Contributor), He, Z. (Contributor), Choi, H. G. (Contributor), Wang, Y. (Contributor), Silvennoinen, O. (Contributor), Hubbard, S. R. (Contributor), Zhang, T. (Contributor), Gray, N. S. (Contributor) & Li, L. S. (Contributor), Protein Data Bank (PDB), Jun 21 2023

    DOI: 10.2210/pdb7TEU, https://www.wwpdb.org/pdb?id=pdb_00007teu

    Dataset