New stable backbone linker resins for solid-phase peptide synthesis

Wenxin Gu, Richard B Silverman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

(Matrix presented) Two new 4-methoxybenzaldehyde backbone linker resins were developed for the solid-phase synthesis of peptides. The linkers are very stable during the cleavage of common protecting groups for amines (Fmoc, Boc) and carboxylic acids (Me, All, tBu) in peptide synthesis. Cleavage from the resin with refluxing TFA is sufficiently mild for peptides containing polar and nonpolar amino acids.

Original languageEnglish (US)
Pages (from-to)415-418
Number of pages4
JournalOrganic Letters
Volume5
Issue number4
DOIs
StatePublished - Feb 20 2003

ASJC Scopus subject areas

  • Molecular Medicine

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