New strategies for the synthesis of N-alkylated indoles (review)

A. V. Karchava*, F. S. Melkonyan, M. A. Yurovskaya

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

New data, mostly published in the last five years, on methods for the synthesis of N-alkylated indoles both as a result of direct introduction of the alkyl substituent at the nitrogen atom and by construction of the indole heterocyclic system are reviewed. Only examples of indole derivatives containing branched, sterically hindered, and chiral alkyl substituents at the nitrogen atom are discussed.

Original languageEnglish (US)
Pages (from-to)391-407
Number of pages17
JournalChemistry of Heterocyclic Compounds
Volume48
Issue number3
DOIs
StatePublished - Jun 2012

Keywords

  • Aza-Michael reaction
  • Indole
  • Mitsunobu reaction
  • Natural compounds
  • Transition metal catalysis

ASJC Scopus subject areas

  • Organic Chemistry

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