New strategies for the synthesis of N-alkylated indoles (review)

A. V. Karchava; F. S. Melkonyan; M. A. Yurovskaya

doi:10.1007/s10593-012-1006-2

New strategies for the synthesis of N-alkylated indoles (review)

A. V. Karchava^*, F. S. Melkonyan, M. A. Yurovskaya

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Review article › peer-review

47 Scopus citations

Abstract

New data, mostly published in the last five years, on methods for the synthesis of N-alkylated indoles both as a result of direct introduction of the alkyl substituent at the nitrogen atom and by construction of the indole heterocyclic system are reviewed. Only examples of indole derivatives containing branched, sterically hindered, and chiral alkyl substituents at the nitrogen atom are discussed.

Original language	English (US)
Pages (from-to)	391-407
Number of pages	17
Journal	Chemistry of Heterocyclic Compounds
Volume	48
Issue number	3
DOIs	https://doi.org/10.1007/s10593-012-1006-2
State	Published - Jun 2012

Keywords

Aza-Michael reaction
Indole
Mitsunobu reaction
Natural compounds
Transition metal catalysis

ASJC Scopus subject areas

Organic Chemistry

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10.1007/s10593-012-1006-2

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abstract = "New data, mostly published in the last five years, on methods for the synthesis of N-alkylated indoles both as a result of direct introduction of the alkyl substituent at the nitrogen atom and by construction of the indole heterocyclic system are reviewed. Only examples of indole derivatives containing branched, sterically hindered, and chiral alkyl substituents at the nitrogen atom are discussed.",

keywords = "Aza-Michael reaction, Indole, Mitsunobu reaction, Natural compounds, Transition metal catalysis",

author = "Karchava, {A. V.} and Melkonyan, {F. S.} and Yurovskaya, {M. A.}",

year = "2012",

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language = "English (US)",

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AU - Karchava, A. V.

AU - Melkonyan, F. S.

AU - Yurovskaya, M. A.

PY - 2012/6

Y1 - 2012/6

N2 - New data, mostly published in the last five years, on methods for the synthesis of N-alkylated indoles both as a result of direct introduction of the alkyl substituent at the nitrogen atom and by construction of the indole heterocyclic system are reviewed. Only examples of indole derivatives containing branched, sterically hindered, and chiral alkyl substituents at the nitrogen atom are discussed.

AB - New data, mostly published in the last five years, on methods for the synthesis of N-alkylated indoles both as a result of direct introduction of the alkyl substituent at the nitrogen atom and by construction of the indole heterocyclic system are reviewed. Only examples of indole derivatives containing branched, sterically hindered, and chiral alkyl substituents at the nitrogen atom are discussed.

KW - Aza-Michael reaction

KW - Indole

KW - Mitsunobu reaction

KW - Natural compounds

KW - Transition metal catalysis

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DO - 10.1007/s10593-012-1006-2

M3 - Review article

AN - SCOPUS:85027921704

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EP - 407

JO - Chemistry of Heterocyclic Compounds

JF - Chemistry of Heterocyclic Compounds

IS - 3

ER -

New strategies for the synthesis of N-alkylated indoles (review)

Abstract

Keywords

ASJC Scopus subject areas

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