TY - JOUR
T1 - New understanding about calcific aortic stenosis and opportunities for pharmacologic intervention
AU - Moura, Luis M.
AU - Maganti, Kameswari
AU - Puthumana, Jyothy J.
AU - Rocha-Gonçalves, F.
AU - Rajamannan, Nalini M.
PY - 2007/11
Y1 - 2007/11
N2 - PURPOSE OF REVIEW: This review article will discuss aortic stenosis, the evolving studies defining the cellular mechanisms and the potential for medical therapies for the treatment of this disease. RECENT FINDINGS: Currently, the only therapy for these patients is surgical valve replacement. In the past decade there has been a change in the paradigm towards our understanding of the cellular biology of this disease process. Studies in laboratories across the world have demonstrated that this disease has an active biology and that this biology may be targeted with medical therapies similar to that of vascular atherosclerosis. SUMMARY: Calcific aortic stenosis is the third most common form of cardiovascular disease in the USA. It has replaced rheumatic heart disease in prevalence in western countries due to improved access to healthcare and the widespread use of antibiotics.
AB - PURPOSE OF REVIEW: This review article will discuss aortic stenosis, the evolving studies defining the cellular mechanisms and the potential for medical therapies for the treatment of this disease. RECENT FINDINGS: Currently, the only therapy for these patients is surgical valve replacement. In the past decade there has been a change in the paradigm towards our understanding of the cellular biology of this disease process. Studies in laboratories across the world have demonstrated that this disease has an active biology and that this biology may be targeted with medical therapies similar to that of vascular atherosclerosis. SUMMARY: Calcific aortic stenosis is the third most common form of cardiovascular disease in the USA. It has replaced rheumatic heart disease in prevalence in western countries due to improved access to healthcare and the widespread use of antibiotics.
KW - Calcific aortic stenosis
KW - Statins and hypercholesterolemia
UR - http://www.scopus.com/inward/record.url?scp=35148849128&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35148849128&partnerID=8YFLogxK
U2 - 10.1097/HCO.0b013e3282f0dae6
DO - 10.1097/HCO.0b013e3282f0dae6
M3 - Review article
C2 - 17921746
AN - SCOPUS:35148849128
SN - 0268-4705
VL - 22
SP - 572
EP - 577
JO - Current opinion in cardiology
JF - Current opinion in cardiology
IS - 6
ER -
