New Views of Old Proteins: Clarifying the Enigmatic Proteome

Kristin E. Burnum-Johnson; Thomas P. Conrads; Richard R. Drake; Amy E. Herr; Ravi Iyengar; Ryan T. Kelly; Emma Lundberg; Michael J. MacCoss; Alexandra Naba; Garry P. Nolan; Pavel A. Pevzner; Karin D. Rodland; Salvatore Sechi; Nikolai Slavov; Jeffrey M. Spraggins; Jennifer E. Van Eyk; Marc Vidal; Christine Vogel; David R. Walt; Neil L. Kelleher

doi:10.1016/j.mcpro.2022.100254

New Views of Old Proteins: Clarifying the Enigmatic Proteome

Kristin E. Burnum-Johnson^*, Thomas P. Conrads, Richard R. Drake, Amy E. Herr, Ravi Iyengar, Ryan T. Kelly, Emma Lundberg, Michael J. MacCoss, Alexandra Naba, Garry P. Nolan, Pavel A. Pevzner, Karin D. Rodland, Salvatore Sechi, Nikolai Slavov, Jeffrey M. Spraggins, Jennifer E. Van Eyk, Marc Vidal, Christine Vogel, David R. Walt, Neil L. Kelleher^*

^*Corresponding author for this work

Molecular Biosciences

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

All human diseases involve proteins, yet our current tools to characterize and quantify them are limited. To better elucidate proteins across space, time, and molecular composition, we provide a >10 years of projection for technologies to meet the challenges that protein biology presents. With a broad perspective, we discuss grand opportunities to transition the science of proteomics into a more propulsive enterprise. Extrapolating recent trends, we describe a next generation of approaches to define, quantify, and visualize the multiple dimensions of the proteome, thereby transforming our understanding and interactions with human disease in the coming decade.

Original language	English (US)
Article number	100254
Journal	Molecular and Cellular Proteomics
Volume	21
Issue number	7
DOIs	https://doi.org/10.1016/j.mcpro.2022.100254
State	Published - Jul 2022

Funding

Funding and additional information—C. V. was supported by awards R35GM127089, 75N93019C00052, and the Chan Zuckerberg Initiative; K. E. B.-J. was supported by award UH3 CA255132-03; N. L. K. by UH3 CA246635-02; G. P. N. by U54 HG010426-03; and J. M. S. U54 DK120058-03, all of which are part of the Human Biomolecular Atlas Program. A. N. was supported by R01 CA232517 and Catalyst Award C-088 from the Chicago Biomedical Consortium, United States. A. E. H. was supported by a National Institutes of Health Cancer Moonshot, United States grant (grant no.: R33CA225296) and as a Chan Zuckerberg Biohub Investigator. E. L. was supported by the KAW Foundation (grant nos.: 2016.0204 and 2018.0172), the Swedish Research Council, Sweden (grant no.: 2017-05327), and the Chan Zuckerberg Initiative, United States (grant no.: CZF2019-002448). N. S. was supported by DP2GM123497 and CZF2019-002424, and N. S. and N. L. K. were supported by Allen Distinguished Investigator awards through the Paul G. Allen Frontiers Group. R. T. K. was supported by R01 GM138931.

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.mcpro.2022.100254

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Burnum-Johnson, K. E., Conrads, T. P., Drake, R. R., Herr, A. E., Iyengar, R., Kelly, R. T., Lundberg, E., MacCoss, M. J., Naba, A., Nolan, G. P., Pevzner, P. A., Rodland, K. D., Sechi, S., Slavov, N., Spraggins, J. M., Van Eyk, J. E., Vidal, M., Vogel, C., Walt, D. R., & Kelleher, N. L. (2022). New Views of Old Proteins: Clarifying the Enigmatic Proteome. Molecular and Cellular Proteomics, 21(7), Article 100254. https://doi.org/10.1016/j.mcpro.2022.100254

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title = "New Views of Old Proteins: Clarifying the Enigmatic Proteome",

abstract = "All human diseases involve proteins, yet our current tools to characterize and quantify them are limited. To better elucidate proteins across space, time, and molecular composition, we provide a >10 years of projection for technologies to meet the challenges that protein biology presents. With a broad perspective, we discuss grand opportunities to transition the science of proteomics into a more propulsive enterprise. Extrapolating recent trends, we describe a next generation of approaches to define, quantify, and visualize the multiple dimensions of the proteome, thereby transforming our understanding and interactions with human disease in the coming decade.",

author = "Burnum-Johnson, {Kristin E.} and Conrads, {Thomas P.} and Drake, {Richard R.} and Herr, {Amy E.} and Ravi Iyengar and Kelly, {Ryan T.} and Emma Lundberg and MacCoss, {Michael J.} and Alexandra Naba and Nolan, {Garry P.} and Pevzner, {Pavel A.} and Rodland, {Karin D.} and Salvatore Sechi and Nikolai Slavov and Spraggins, {Jeffrey M.} and {Van Eyk}, {Jennifer E.} and Marc Vidal and Christine Vogel and Walt, {David R.} and Kelleher, {Neil L.}",

note = "Publisher Copyright: {\textcopyright} 2022 THE AUTHORS.",

year = "2022",

month = jul,

doi = "10.1016/j.mcpro.2022.100254",

language = "English (US)",

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Burnum-Johnson, KE, Conrads, TP, Drake, RR, Herr, AE, Iyengar, R, Kelly, RT, Lundberg, E, MacCoss, MJ, Naba, A, Nolan, GP, Pevzner, PA, Rodland, KD, Sechi, S, Slavov, N, Spraggins, JM, Van Eyk, JE, Vidal, M, Vogel, C, Walt, DR & Kelleher, NL 2022, 'New Views of Old Proteins: Clarifying the Enigmatic Proteome', Molecular and Cellular Proteomics, vol. 21, no. 7, 100254. https://doi.org/10.1016/j.mcpro.2022.100254

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AU - Iyengar, Ravi

AU - Kelly, Ryan T.

AU - Lundberg, Emma

AU - MacCoss, Michael J.

AU - Naba, Alexandra

AU - Nolan, Garry P.

AU - Pevzner, Pavel A.

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AU - Sechi, Salvatore

AU - Slavov, Nikolai

AU - Spraggins, Jeffrey M.

AU - Van Eyk, Jennifer E.

AU - Vidal, Marc

AU - Vogel, Christine

AU - Walt, David R.

AU - Kelleher, Neil L.

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New Views of Old Proteins: Clarifying the Enigmatic Proteome

Abstract

Funding

ASJC Scopus subject areas

UN SDGs

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