Newly diagnosed enhancing lesions: Steroid initiation may impede diagnosis of lymphoma involving the central nervous system

Kwok Ling Kam*, Sarah M. Brooker, Qinwen Mao, Liron Barnea Slonim, Nabeel R. Yaseen, Daniel J. Brat, Adam M. Sonabend, Rimas V. Lukas

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Establishing the pathologic diagnosis of central nervous system (CNS) lymphoma can be challenging, yet management of this potentially curable disease depends heavily on it. One avoidable impediment to obtaining an accurate and timely diagnosis is the pre-operative administration of steroids, which causes tumor involution and prevents appropriate sampling of viable tissue. We discuss a case of primary CNS lymphoma that highlights the evolution of the disease and the attempts to establish a diagnosis in the setting of prior administration of corticosteroids. Familiarity with these clinical scenarios will help others avoid delays in patient care that results from delayed diagnosis.

Original languageEnglish (US)
Pages (from-to)61-64
Number of pages4
JournalJournal of Clinical Neuroscience
Volume81
DOIs
StatePublished - Nov 2020

Keywords

  • Diagnosis
  • Lymphoma
  • PCNSL
  • Primary CNS lymphoma
  • Steroids

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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