TY - JOUR
T1 - Newly identified prions in budding yeast, and their possible functions
AU - Crow, Emily T.
AU - Li, Liming
N1 - Funding Information:
This work was supported by a grant from the U.S. National Institutes of Health ( R01NS056086 ) to L.L.
PY - 2011/7
Y1 - 2011/7
N2 - Yeast prions are atypical genetic elements that are transmitted as heritable protein conformations. [PSI+], [URE3], and [PIN+] are three well-studied prions in the budding yeast, Saccharomyces cerevisiae. In the last three years, several additional prions have been reported in yeast, including [SWI+], [OCT+], [MCA], [GAR+], [MOT3+], [ISP+], and [NSI+]. The growing number of yeast prions suggests that protein-based inheritance might be a widespread biological phenomenon. In this review, we summarize the characteristics of each prion element, and discuss their potential functional roles in yeast biology.
AB - Yeast prions are atypical genetic elements that are transmitted as heritable protein conformations. [PSI+], [URE3], and [PIN+] are three well-studied prions in the budding yeast, Saccharomyces cerevisiae. In the last three years, several additional prions have been reported in yeast, including [SWI+], [OCT+], [MCA], [GAR+], [MOT3+], [ISP+], and [NSI+]. The growing number of yeast prions suggests that protein-based inheritance might be a widespread biological phenomenon. In this review, we summarize the characteristics of each prion element, and discuss their potential functional roles in yeast biology.
KW - Amyloid
KW - Epigenetics
KW - Prion
KW - Protein aggregation
KW - Yeast
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U2 - 10.1016/j.semcdb.2011.03.003
DO - 10.1016/j.semcdb.2011.03.003
M3 - Review article
C2 - 21397710
AN - SCOPUS:80053569315
SN - 1084-9521
VL - 22
SP - 452
EP - 459
JO - Seminars in Cell Biology
JF - Seminars in Cell Biology
IS - 5
ER -