Newt limb regeneration studied with synchrotron microCT

Stuart R Stock*, K. I. Ignatiev, Hans-Georg Simon, F. De Carlo

*Corresponding author for this work

Research output: Contribution to journalConference article

2 Scopus citations

Abstract

Newts are the most developed vertebrates which retain the ability as adults to regenerate missing limbs; they are, therefore, of great interest in terms understanding how such regeneration could be triggered in mammals. In this study, synchrotron microCT was used to study bone microstructure in control forelimbs and in forelimbs regenerated for periods from 37 to 85 days. The bone microstructure in newts has been largely neglected, and interesting patterns within the original bone and in the regenerating arm and hand are described. Periosteal bone formation in the regenerating arm and finger bones, delayed ossification of carpal (but not metacarpal) bones and the complex microstructure of the original carpal bones are areas where microCT reveals detail of particular interest.

Original languageEnglish (US)
Article number86
Pages (from-to)748-756
Number of pages9
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume5535
DOIs
StatePublished - Dec 1 2004
EventDevelopments in X-Ray Tomography IV - Denver, CO, United States
Duration: Aug 4 2004Aug 6 2004

Keywords

  • Bone
  • MicroCT
  • Newt
  • Regeneration

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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