The article discusses the potential use of gold nanoparticles in next-generation biosensing techniques. Gold nanoparticle probes offer significant advantages over molecular-fluorophore probes in terms of selectivity and sensitivity in DNA detection. From a technological perspective, the sharp melting transitions exhibited by DNA-nanoparticle conjugates are extremely important because the sharpness of the DNA-melting transition effectively determines the selectivity of any hybridization-based assay.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Jul 2003|
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