Next-generation biosensing with gold nanoparticles

David S. Ginger*, Y. Charles Cao, Chad A. Mirkin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The article discusses the potential use of gold nanoparticles in next-generation biosensing techniques. Gold nanoparticle probes offer significant advantages over molecular-fluorophore probes in terms of selectivity and sensitivity in DNA detection. From a technological perspective, the sharp melting transitions exhibited by DNA-nanoparticle conjugates are extremely important because the sharpness of the DNA-melting transition effectively determines the selectivity of any hybridization-based assay.

Original languageEnglish (US)
Pages (from-to)48-51
Number of pages4
JournalBiophotonics International
Issue number6
StatePublished - Jul 2003

ASJC Scopus subject areas

  • Biotechnology


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