NF-ΚB and IRF pathways: Cross-regulation on target genes promoter level

Marta Iwanaszko*, Marek Kimmel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Background: The NF-ΚB and IRF transcription factor families are major players in inflammation and antiviral response and act as two major effectors of the innate immune response (IIR). The regulatory mechanisms of activation of these two pathways and their interactions during the IIR are only partially known. Results: Our in silico findings report that there is cross-regulation between both pathways at the level of gene transcription regulation, mediated by the presence of binding sites for both factors in promoters of genes essential for these pathways. These findings agree with recent experimental data reporting crosstalk between pathways activated by RIG-I and TLR3 receptors in response to pathogens. Conclusions: We present an extended crosstalk diagram of the IRF - NF-ΚB pathways. We conclude that members of the NF-ΚB family may directly impact regulation of IRF family, while IRF members impact regulation of NF-ΚB family rather indirectly, via other transcription factors such as AP-1 and SP1.

Original languageEnglish (US)
Article number307
JournalBMC Genomics
Volume16
Issue number1
DOIs
StatePublished - Apr 17 2015

Keywords

  • Crosstalk
  • IRF3
  • Innate immune response
  • NF-ΚB
  • Transcription factors

ASJC Scopus subject areas

  • Biotechnology
  • Genetics

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