Nimodipine facilitates associative learning in aging rabbits

Richard A. Deyo, Karen T. Straube, John F. Disterhoft*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

264 Scopus citations

Abstract

Nimodipine is one of several dihydropyridines that block calcium channels. Originally administered to improve cerebral blood flow in elderly patients with chronic cerebro vascular disorders, nimodipine was noted to facilitate learning. These observations led to the present investigation of the effects of nimodipine on associative learning in aging rabbits. Nimodipine accelerated acquisition of conditioned eye-blink in both young and aging rabbits without altering the amplitude of responses to the conditioned or unconditioned stimuli or causing nonspecific responding. Thus, nimodipine may be a candidate for an effective treatment for age-related learning deficits.

Original languageEnglish (US)
Pages (from-to)809-811
Number of pages3
JournalScience
Volume243
Issue number4892
DOIs
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • General

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