Nimodipine potentiates light-induced phase shifts of circadian activity rhythms but not c-fos expression in the suprachiasmatic nucleus of mice

Susan Benloucif; Monica I. Masana; Phyllis C. Zee; Margarita L. Dubocovich

doi:10.1016/S0006-8993(02)04195-1

Nimodipine potentiates light-induced phase shifts of circadian activity rhythms but not c-fos expression in the suprachiasmatic nucleus of mice

Susan Benloucif^*, Monica I. Masana, Phyllis C. Zee, Margarita L. Dubocovich

^*Corresponding author for this work

CSCB - Center for Sleep and Circadian Biology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The present study assessed whether treatment with the L-type calcium channel antagonist nimodipine affects the responsiveness of the circadian pacemaker to light in C3H/HeN mice. Nimodipine (10 mg/kg, sc) increased the magnitude of light-induced phase delays (P<0.01) and c-fos mRNA expression in the paraventricular nuclei (P<0.01), but not in the suprachiasmatic nuclei (SCN). These results suggest that nimodipine may affect phase shifts of circadian activity rhythms through a mechanism independent of c-fos expression in the SCN.

Original language	English (US)
Pages (from-to)	157-161
Number of pages	5
Journal	Brain research
Volume	966
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(02)04195-1
State	Published - Mar 14 2003

Funding

Keywords

Calcium
Calcium antagonist
Immediate early gene
Phase delay

ASJC Scopus subject areas

Clinical Neurology
Molecular Biology
General Neuroscience
Developmental Biology

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10.1016/S0006-8993(02)04195-1

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abstract = "The present study assessed whether treatment with the L-type calcium channel antagonist nimodipine affects the responsiveness of the circadian pacemaker to light in C3H/HeN mice. Nimodipine (10 mg/kg, sc) increased the magnitude of light-induced phase delays (P<0.01) and c-fos mRNA expression in the paraventricular nuclei (P<0.01), but not in the suprachiasmatic nuclei (SCN). These results suggest that nimodipine may affect phase shifts of circadian activity rhythms through a mechanism independent of c-fos expression in the SCN.",

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AU - Benloucif, Susan

AU - Masana, Monica I.

AU - Zee, Phyllis C.

AU - Dubocovich, Margarita L.

PY - 2003/3/14

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AB - The present study assessed whether treatment with the L-type calcium channel antagonist nimodipine affects the responsiveness of the circadian pacemaker to light in C3H/HeN mice. Nimodipine (10 mg/kg, sc) increased the magnitude of light-induced phase delays (P<0.01) and c-fos mRNA expression in the paraventricular nuclei (P<0.01), but not in the suprachiasmatic nuclei (SCN). These results suggest that nimodipine may affect phase shifts of circadian activity rhythms through a mechanism independent of c-fos expression in the SCN.

KW - Calcium

KW - Calcium antagonist

KW - Immediate early gene

KW - Phase delay

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Nimodipine potentiates light-induced phase shifts of circadian activity rhythms but not c-fos expression in the suprachiasmatic nucleus of mice

Abstract

Funding

Keywords

ASJC Scopus subject areas

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