Nitric oxide cell signaling: S-nitrosation of Ras superfamily GTPases

Kimberly W. Raines, Marcelo G. Bonini, Sharon L. Campbell*

*Corresponding author for this work

Research output: Contribution to journalReview article

44 Scopus citations

Abstract

The Ras superfamily of small GTPases cycle between inactive GDP-bound and active GTP-bound states to modulate a diverse array of processes involved in cellular growth control. While the basic mechanisms by which GTPase regulatory proteins regulate GTPase substrates have been revealed through numerous studies, detailed studies into the mechanism(s) of free radical-mediated GTPase regulation have only more recently been tackled. This article reviews the mechanism of free radical-mediated GTPase regulation and shows nitric oxide can serve as important regulator of small GTPase proteins (i.e. Ras and RhoA) through protein modifications such as S-nitrosation.

Original languageEnglish (US)
Pages (from-to)229-239
Number of pages11
JournalCardiovascular research
Volume75
Issue number2
DOIs
StatePublished - Jul 15 2007
Externally publishedYes

Keywords

  • Nitric oxide
  • Redox signaling
  • Small GTPases

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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