Nitric Oxide-Delivering High-Density Lipoprotein-like Nanoparticles as a Biomimetic Nanotherapy for Vascular Diseases

Jonathan S. Rink, Wangqiang Sun, Sol Misener, Jiao Jing Wang, Zheng Jenny Zhang, Melina R. Kibbe, Vinayak P. Dravid, Subbu Venkatraman, C. Shad Thaxton*

*Corresponding author for this work

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Disorders of blood vessels cause a range of severe health problems. As a powerful vasodilator and cellular second messenger, nitric oxide (NO) is known to have beneficial vascular functions. However, NO typically has a short half-life and is not specifically targeted. On the other hand, high-density lipoproteins (HDLs) are targeted natural nanoparticles (NPs) that transport cholesterol in the systemic circulation and whose protective effects in vascular homeostasis overlap with those of NO. Evolving the AuNP-templated HDL-like nanoparticles (HDL NPs), a platform of bioinspired HDL, we set up a targeted biomimetic nanotherapy for vascular disease that combines the functions of NO and HDL. A synthetic S-nitrosylated (SNO) phospholipid (1,2-dipalmitoyl-sn-glycero-3-phosphonitrosothioethanol) was synthesized and assembled with S-containing phospholipids and the principal protein of HDL, apolipoprotein A-I, to construct NO-delivering HDL-like particles (SNO HDL NPs). SNO HDL NPs self-assemble under mild conditions similar to natural processes, avoiding the complex postassembly modification needed for most synthetic NO-release nanoparticles. In vitro data demonstrate that the SNO HDL NPs merge the functional properties of NO and HDL into a targeted nanocarrier. Also, SNO HDL NPs were demonstrated to reduce ischemia/reperfusion injury in vivo in a mouse kidney transplant model and atherosclerotic plaque burden in a mouse model of atherosclerosis. Thus, the synthesis of SNO HDL NPs provides not only a bioinspired nanotherapy for vascular disease but also a foundation to construct diversified multifunctional platforms based on HDL NPs in the future.

Original languageEnglish (US)
Pages (from-to)6904-6916
Number of pages13
JournalACS Applied Materials and Interfaces
Volume10
Issue number8
DOIs
StatePublished - Feb 28 2018

Fingerprint

Lipoproteins
Nitric oxide
Biomimetics
HDL Lipoproteins
Nitric Oxide
Nanoparticles
Phospholipids
Transplants
Cholesterol
Apolipoprotein A-I
Blood vessels
Second Messenger Systems
Medical problems
Vasodilator Agents

Keywords

  • S-nitrosylation
  • biomimetic
  • high-density lipoprotein-like nanoparticles
  • nanotherapy
  • nitric oxide-delivering
  • vascular disease

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Rink, Jonathan S. ; Sun, Wangqiang ; Misener, Sol ; Wang, Jiao Jing ; Zhang, Zheng Jenny ; Kibbe, Melina R. ; Dravid, Vinayak P. ; Venkatraman, Subbu ; Thaxton, C. Shad. / Nitric Oxide-Delivering High-Density Lipoprotein-like Nanoparticles as a Biomimetic Nanotherapy for Vascular Diseases. In: ACS Applied Materials and Interfaces. 2018 ; Vol. 10, No. 8. pp. 6904-6916.
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Nitric Oxide-Delivering High-Density Lipoprotein-like Nanoparticles as a Biomimetic Nanotherapy for Vascular Diseases. / Rink, Jonathan S.; Sun, Wangqiang; Misener, Sol; Wang, Jiao Jing; Zhang, Zheng Jenny; Kibbe, Melina R.; Dravid, Vinayak P.; Venkatraman, Subbu; Thaxton, C. Shad.

In: ACS Applied Materials and Interfaces, Vol. 10, No. 8, 28.02.2018, p. 6904-6916.

Research output: Contribution to journalArticle

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AU - Rink, Jonathan S.

AU - Sun, Wangqiang

AU - Misener, Sol

AU - Wang, Jiao Jing

AU - Zhang, Zheng Jenny

AU - Kibbe, Melina R.

AU - Dravid, Vinayak P.

AU - Venkatraman, Subbu

AU - Thaxton, C. Shad

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