Nitric oxide: What a vascular surgeon needs to know

Daniel A. Popowich, Vinit Varu, Melina R. Kibbe*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Atherosclerosis in the form of peripheral arterial disease results in significant morbidity and mortality. Surgical treatment options for peripheral arterial disease include angioplasty with and without stenting, endarterectomy, and bypass grafting. Unfortunately, all of these procedures injure the vascular endothelium, which impairs its ability to produce nitric oxide (NO) and ultimately leads to neointimal hyperplasia and restenosis. To improve on current patency rates after vascular procedures, investigators are engaged in research to improve the bioavailability of NO at the site of vascular injury in an attempt to reduce the risk of thrombosis and restenosis after successful revascularization. This article reviews some of the previous research that has aimed to improve NO bioavailability after vascular procedures whether through systemic or local delivery, as well as to describe some of the NO-releasing products that are currently undergoing study for use in clinical practice.

Original languageEnglish (US)
Pages (from-to)324-335
Number of pages12
Issue number6
StatePublished - Nov 1 2007


  • Atherosclerosis
  • Neointimal hyperplasia
  • Nitric oxide
  • Peripheral vascular disease
  • Restenosis

ASJC Scopus subject areas

  • Surgery
  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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