NKG2D and its ligands in cancer

Payal Dhar, Jennifer D. Wu

Research output: Contribution to journalReview articlepeer-review

131 Scopus citations


NKG2D is an activating immune receptor expressed by NK and effector T cells. Induced expression of NKG2D ligand on tumor cell surface during oncogenic insults renders cancer cells susceptible to immune destruction. In advanced human cancers, tumor cells shed NKG2D ligand to produce an immune soluble form as a means of immune evasion. Soluble NKG2D ligands have been associated with poor clinical prognosis in cancer patients. Harnessing NKG2D pathway is considered a viable avenue in cancer immunotherapy over recent years. In this review, we will discuss the progress and perspectives.

Original languageEnglish (US)
Pages (from-to)55-61
Number of pages7
JournalCurrent Opinion in Immunology
StatePublished - Apr 2018

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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