NLRP7 and related inflammasome activating pattern recognition receptors and their function in host defense and disease

Alexander D. Radian, Lucia de Almeida, Andrea Dorfleutner, Christian Stehlik*

*Corresponding author for this work

Research output: Contribution to journalShort survey

23 Scopus citations

Abstract

Host defense requires the maturation and release of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 and the induction of pyroptotic cell death, which depends on the activation of inflammatory Caspases within inflammasomes by innate immune cells. Several cytosolic pattern recognition receptors (PRRs) have been implicated in this process in response to infectious and sterile agonists. Here we summarize the current knowledge on inflammasome-organizing PRRs, emphasizing the recently described NLRP7, and their implications in human disease.

Original languageEnglish (US)
Pages (from-to)630-639
Number of pages10
JournalMicrobes and Infection
Volume15
Issue number8-9
DOIs
StatePublished - Jul 2013

Keywords

  • AIM2-like receptor
  • Hydatidiform mole
  • Inflammasome
  • Inflammation
  • Nod-like receptor
  • Pattern recognition receptor

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

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