No Evidence for Association of Dopamine D2 Receptor Variant (Ser311/Cys311) with Major Psychosis

Tsukasa Sasaki, Fabio M. Macciardi, Farideh Badri, Massimiliano Verga, Herbert Y. Meltzer, Jeffrey Lieberman, Alfreda Howard, Graham Bean, Russel T. Joffe, Craig J. Hudson, James L. Kennedy*

*Corresponding author for this work

Research output: Contribution to journalArticle

33 Scopus citations


We investigated a variant of the dopamine D2 receptor gene (Ser311/Cys311 substitution) in Caucasian patients with schizophrenia (n = 273), delusional disorder (n = 62), bipolar I affective disorder (n = 63), and controls (n = 255). No evidence for association between the receptor variant and any of the diseases was found, even when patients with younger age-of-onset (<25 years) were compared with controls. Furthermore, in a subgroup of schizophrenia patients whom we assessed for negative symptoms, those with the Cys allele did not differ from the remainder of the group. Also, the bipolar affective disorder patients with psychotic features did not show evidence for association with the receptor variant. Thus, our results do not provide evidence for an association between this D2 receptor variant and schizophrenia, or delusional disorder, or bipolar affective disorder.

Original languageEnglish (US)
Pages (from-to)415-417
Number of pages3
JournalAmerican Journal of Medical Genetics, Part C: Seminars in Medical Genetics
Issue number4
StatePublished - Jul 26 1996


  • Bipolar affective disorder
  • Delusional disorder
  • Dopamine D2 receptor
  • Genetics
  • Schizophrenia

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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