NO more muscle fatigue

Ahlke Heydemann, Elizabeth McNally*

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

34 Scopus citations


NOS is a key enzyme in the production of NO, a molecule that directly regulates vasorelaxation and blood supply. Diverse forms of muscle disease have been clinically associated with unusual fatigue after exercise. The localization of neuronal NOS (nNOS) at the plasma membrane of muscle has recently been shown to prevent muscle fatigue after exercise. In this issue of the JCI, Lai et al. show that dystrophin - the structural protein missing in individuals with Duchenne muscular dystrophy - anchors nNOS to the sarcolemma through a direct interaction with dystrophin spectrin-like repeats 16 and 17 (see the related article beginning on page 624). Furthermore, in another recently reported study of mouse models of muscular dystrophy, phosphodiesterase 5A inhibitors were used to treat the downstream ischemia that is associated with nNOS mislocalization. Collectively, these findings significantly advance our understanding of exercise-induced muscle fatigue and its role in muscle disease.

Original languageEnglish (US)
Pages (from-to)448-450
Number of pages3
JournalJournal of Clinical Investigation
Issue number3
StatePublished - Mar 2 2009

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'NO more muscle fatigue'. Together they form a unique fingerprint.

Cite this